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Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study

Overview of attention for article published in Stem Cell Research & Therapy, March 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

twitter
8 tweeters
facebook
1 Facebook page

Citations

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79 Dimensions

Readers on

mendeley
145 Mendeley
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Title
Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study
Published in
Stem Cell Research & Therapy, March 2017
DOI 10.1186/s13287-017-0506-5
Pubmed ID
Authors

Misako Nakashima, Koichiro Iohara, Masashi Murakami, Hiroshi Nakamura, Yayoi Sato, Yoshiko Ariji, Kenji Matsushita

Abstract

Experiments have previously demonstrated the therapeutic potential of mobilized dental pulp stem cells (MDPSCs) for complete pulp regeneration. The aim of the present pilot clinical study is to assess the safety, potential efficacy, and feasibility of autologous transplantation of MDPSCs in pulpectomized teeth. Five patients with irreversible pulpitis were enrolled and monitored for up to 24 weeks following MDPSC transplantation. The MDPSCs were isolated from discarded teeth and expanded based on good manufacturing practice (GMP). The quality of the MDPSCs at passages 9 or 10 was ascertained by karyotype analyses. The MDPSCs were transplanted with granulocyte colony-stimulating factor (G-CSF) in atelocollagen into pulpectomized teeth. The clinical and laboratory evaluations demonstrated no adverse events or toxicity. The electric pulp test (EPT) of the pulp at 4 weeks demonstrated a robust positive response. The signal intensity of magnetic resonance imaging (MRI) of the regenerated tissue in the root canal after 24 weeks was similar to that of normal dental pulp in the untreated control. Finally, cone beam computed tomography demonstrated functional dentin formation in three of the five patients. Human MDPSCs are safe and efficacious for complete pulp regeneration in humans in this pilot clinical study.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 144 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 24 17%
Student > Bachelor 19 13%
Student > Ph. D. Student 16 11%
Student > Doctoral Student 14 10%
Researcher 12 8%
Other 30 21%
Unknown 30 21%
Readers by discipline Count As %
Medicine and Dentistry 79 54%
Biochemistry, Genetics and Molecular Biology 12 8%
Agricultural and Biological Sciences 6 4%
Materials Science 2 1%
Pharmacology, Toxicology and Pharmaceutical Science 2 1%
Other 6 4%
Unknown 38 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2018.
All research outputs
#3,322,710
of 14,371,551 outputs
Outputs from Stem Cell Research & Therapy
#317
of 1,310 outputs
Outputs of similar age
#72,966
of 259,412 outputs
Outputs of similar age from Stem Cell Research & Therapy
#5
of 14 outputs
Altmetric has tracked 14,371,551 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,310 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,412 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.