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Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons

Overview of attention for article published in BMC Neuroscience, September 2013
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Mentioned by

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2 tweeters

Citations

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19 Dimensions

Readers on

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37 Mendeley
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Title
Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons
Published in
BMC Neuroscience, September 2013
DOI 10.1186/1471-2202-14-96
Pubmed ID
Authors

James A Green, Jun Yang, M’hamed Grati, Bechara Kachar, Manzoor A Bhat

Abstract

Myelinated axons are organized into distinct subcellular and molecular regions. Without proper organization, electrical nerve conduction is delayed, resulting in detrimental physiological outcomes. One such region is the paranode where axo-glial septate junctions act as a molecular fence to separate the sodium (Na+) channel-enriched node from the potassium (K+) channel-enriched juxtaparanode. A significant lack of knowledge remains as to cytoskeletal proteins which stabilize paranodal domains and underlying cytoskeleton. Whirlin (Whrn) is a PDZ domain-containing cytoskeletal scaffold whose absence in humans results in Usher Syndromes or variable deafness-blindness syndromes. Mutant Whirlin (Whrn) mouse model studies have linked such behavioral deficits to improper localization of critical transmembrane protein complexes in the ear and eye. Until now, no reports exist about the function of Whrn in myelinated axons.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Researcher 7 19%
Student > Ph. D. Student 7 19%
Student > Bachelor 6 16%
Professor 4 11%
Other 4 11%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 30%
Neuroscience 8 22%
Biochemistry, Genetics and Molecular Biology 6 16%
Medicine and Dentistry 5 14%
Psychology 1 3%
Other 2 5%
Unknown 4 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2013.
All research outputs
#9,508,178
of 12,372,276 outputs
Outputs from BMC Neuroscience
#646
of 993 outputs
Outputs of similar age
#99,492
of 155,502 outputs
Outputs of similar age from BMC Neuroscience
#3
of 8 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 993 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.