Title |
Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells
|
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Published in |
Cancer & Metabolism, September 2013
|
DOI | 10.1186/2049-3002-1-19 |
Pubmed ID | |
Authors |
Julia Billiard, Jennifer B Dennison, Jacques Briand, Roland S Annan, Deping Chai, Mariela Colón, Christopher S Dodson, Seth A Gilbert, Joel Greshock, Junping Jing, Hong Lu, Jeanelle E McSurdy-Freed, Lisa A Orband-Miller, Gordon B Mills, Chad J Quinn, Jessica L Schneck, Gilbert F Scott, Anthony N Shaw, Gregory M Waitt, Richard F Wooster, Kevin J Duffy |
Abstract |
Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerobic glycolysis. This glycolytic phenotype is enabled by lactate dehydrogenase (LDH), which catalyzes the inter-conversion of pyruvate and lactate. The purpose of this study was to identify and characterize potent and selective inhibitors of LDHA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 17% |
India | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Czechia | 1 | <1% |
Unknown | 177 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 41 | 23% |
Student > Ph. D. Student | 34 | 19% |
Student > Bachelor | 22 | 12% |
Student > Master | 19 | 11% |
Professor | 6 | 3% |
Other | 18 | 10% |
Unknown | 38 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 37 | 21% |
Agricultural and Biological Sciences | 31 | 17% |
Chemistry | 24 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 8% |
Medicine and Dentistry | 14 | 8% |
Other | 19 | 11% |
Unknown | 39 | 22% |