Title |
Circularity and self-cleavage as a strategy for the emergence of a chromosome in the RNA-based protocell
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Published in |
Biology Direct, August 2013
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DOI | 10.1186/1745-6150-8-21 |
Pubmed ID | |
Authors |
Wentao Ma, Chunwu Yu, Wentao Zhang |
Abstract |
It is now popularly accepted that an "RNA world" existed in early evolution. During division of RNA-based protocells, random distribution of individual genes (simultaneously as ribozymes) between offspring might have resulted in gene loss, especially when the number of gene types increased. Therefore, the emergence of a chromosome carrying linked genes was critical for the prosperity of the RNA world. However, there were quite a few immediate difficulties for this event to occur. For example, a chromosome would be much longer than individual genes, and thus more likely to degrade and less likely to replicate completely; the copying of the chromosome might start at middle sites and be only partial; and, without a complex transcription mechanism, the synthesis of distinct ribozymes would become problematic. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
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Germany | 1 | 3% |
Unknown | 30 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 30% |
Student > Ph. D. Student | 9 | 27% |
Student > Bachelor | 5 | 15% |
Professor | 4 | 12% |
Other | 1 | 3% |
Other | 2 | 6% |
Unknown | 2 | 6% |
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Immunology and Microbiology | 1 | 3% |
Other | 2 | 6% |
Unknown | 3 | 9% |