Title |
Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm
|
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Published in |
Journal of Translational Medicine, September 2013
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DOI | 10.1186/1479-5876-11-208 |
Pubmed ID | |
Authors |
Kirsten Riches, Timothy G Angelini, Gurprit S Mudhar, Jean Kaye, Emily Clark, Marc A Bailey, Soroush Sohrabi, Sotirios Korossis, Peter G Walker, D Julian A Scott, Karen E Porter |
Abstract |
Vascular smooth muscle cells (SMC) are central to arterial structure and function yet their involvement in the progression of abdominal aortic aneurysm (AAA) disease is not well studied. The progressive and silent nature of AAA in man essentially restricts research to the use of "end-stage" tissue recovered during surgical repair. This study aimed to generate an ex vivo model of AAA using protease-treated porcine carotid arteries maintained in a novel bioreactor, and to compare the structural and functional changes in SMC cultured from the recovered vessels with those from human tissue acquired at elective surgical repair. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Austria | 1 | <1% |
Unknown | 113 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 32 | 28% |
Researcher | 31 | 27% |
Student > Ph. D. Student | 12 | 10% |
Student > Master | 9 | 8% |
Student > Bachelor | 8 | 7% |
Other | 9 | 8% |
Unknown | 15 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 55 | 47% |
Medicine and Dentistry | 15 | 13% |
Biochemistry, Genetics and Molecular Biology | 11 | 9% |
Engineering | 7 | 6% |
Materials Science | 3 | 3% |
Other | 7 | 6% |
Unknown | 18 | 16% |