Title |
RETRACTED ARTICLE: Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis
|
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Published in |
Arthritis Research & Therapy, September 2013
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DOI | 10.1186/ar4300 |
Pubmed ID | |
Authors |
Gianluca Bagnato, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Donatella Sangari, Maurizio Cinquegrani, William Neal Roberts, Marco Atteritano, Domenica Altavilla, Francesco Squadrito, Gianfilippo Bagnato, Antonino Saitta |
Abstract |
Recent advances suggest that the cellular redox state may play a significant role in the progression of fibrosis in systemic sclerosis (SSc). Another, and as yet poorly accounted for, feature of SSc is its overlap with thyroid abnormalities. Previous reports demonstrate that hypothyroidism reduces oxidant stress. The aim of this study was therefore to evaluate the effect of propylthiouracil (PTU), and of the hypothyroidism induced by it, on the development of cutaneous and pulmonary fibrosis in the oxidant stress murine model of SSc. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 16% |
Student > Doctoral Student | 4 | 13% |
Student > Ph. D. Student | 4 | 13% |
Student > Postgraduate | 3 | 9% |
Other | 2 | 6% |
Other | 3 | 9% |
Unknown | 11 | 34% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Psychology | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 4 | 13% |
Unknown | 14 | 44% |