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Mendeley readers
Attention Score in Context
| Title |
p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1
|
|---|---|
| Published in |
Nature Communications, August 2013
|
| DOI | 10.1038/ncomms3359 |
| Pubmed ID | |
| Authors |
Bei Wang, Dandan Niu, Liyun Lai, Ee Chee Ren |
| Abstract |
The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, which lacks p53 exhibits significantly lower major histocompatibility complex I expression than its wild-type counterpart. Using a combination of chromatin immunoprecipitation sequencing and gene expression analysis, we demonstrate that p53 upregulates expression of endoplasmic reticulum aminopeptidase 1 by binding to its cognate response element in the ERAP1 gene. Silencing of p53 decreases endoplasmic reticulum aminopeptidase 1 protein levels and therefore major histocompatibility complex I expression. We further show that this mechanism operates in A549 cells infected with H1N1 influenza virus, in which H1N1 activates p53, leading to endoplasmic reticulum aminopeptidase 1 upregulation and a corresponding increase in major histocompatibility complex I expression. Our study suggests a previously unrecognized link between p53 function and the immunosurveillance of cancer and infection. |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | <1% |
| Austria | 1 | <1% |
| Finland | 1 | <1% |
| India | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 150 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 39 | 25% |
| Student > Ph. D. Student | 37 | 24% |
| Student > Bachelor | 14 | 9% |
| Student > Master | 11 | 7% |
| Student > Postgraduate | 8 | 5% |
| Other | 18 | 12% |
| Unknown | 29 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 30% |
| Biochemistry, Genetics and Molecular Biology | 41 | 26% |
| Medicine and Dentistry | 18 | 12% |
| Immunology and Microbiology | 10 | 6% |
| Computer Science | 2 | 1% |
| Other | 7 | 4% |
| Unknown | 31 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2013.
All research outputs
#804,280
of 22,721,584 outputs
Outputs from Nature Communications
#13,418
of 46,770 outputs
Outputs of similar age
#7,475
of 198,941 outputs
Outputs of similar age from Nature Communications
#93
of 359 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,770 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,941 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 359 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.