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Viral complementation allows HIV-1 replication without integration

Overview of attention for article published in Retrovirology, July 2008
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2 X users

Citations

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Title
Viral complementation allows HIV-1 replication without integration
Published in
Retrovirology, July 2008
DOI 10.1186/1742-4690-5-60
Pubmed ID
Authors

Huub C Gelderblom, Dimitrios N Vatakis, Sean A Burke, Steven D Lawrie, Gregory C Bristol, David N Levy

Abstract

The integration of HIV-1 DNA into cellular chromatin is required for high levels of viral gene expression and for the production of new virions. However, the majority of HIV-1 DNA remains unintegrated and is generally considered a replicative dead-end. A limited amount of early gene expression from unintegrated DNA has been reported, but viral replication does not proceed further in cells which contain only unintegrated DNA. Multiple infection of cells is common, and cells that are productively infected with an integrated provirus frequently also contain unintegrated HIV-1 DNA. Here we examine the influence of an integrated provirus on unintegrated HIV-1 DNA (uDNA).

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 6%
Spain 1 1%
France 1 1%
Unknown 74 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 27%
Researcher 20 25%
Professor 6 7%
Professor > Associate Professor 5 6%
Student > Master 5 6%
Other 13 16%
Unknown 10 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 42%
Medicine and Dentistry 14 17%
Biochemistry, Genetics and Molecular Biology 12 15%
Immunology and Microbiology 4 5%
Chemistry 2 2%
Other 4 5%
Unknown 11 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2017.
All research outputs
#15,169,949
of 25,374,647 outputs
Outputs from Retrovirology
#685
of 1,273 outputs
Outputs of similar age
#79,642
of 95,494 outputs
Outputs of similar age from Retrovirology
#9
of 12 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,494 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.