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Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors

Overview of attention for article published in Cancer Cell International, January 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)

Mentioned by

twitter
1 tweeter
patent
3 patents

Citations

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23 Dimensions

Readers on

mendeley
27 Mendeley
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Title
Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors
Published in
Cancer Cell International, January 2013
DOI 10.1186/1475-2867-13-82
Pubmed ID
Authors

Khaled Y Orabi, Mohamed S Abaza, Khalid A El Sayed, Ahmed Y Elnagar, Rajaa Al-Attiyah, Radhika P Guleri

Abstract

It has been shown that proteasome inhibition leads to growth arrest in the G1 phase of the cell cycle and/or induction of apoptosis. However, it was found that some of these inhibitors do not induce apoptosis in several human normal cell lines. This selective activity makes proteasome inhibition a promising target for new generation of anticancer drugs. Clinical validation of the proteasome, as a therapeutic target in oncology, has been provided by the dipeptide boronic acid derivative; bortezomib. Bortezomib has proven to be effective as a single agent in multiple myeloma and some forms of non-Hodgkin's lymphoma. Syringic acid (4-hydroxy-3,5-dimethoxybenzoic acid, 1), a known phenolic acid, was isolated from the methanol extract of Tamarix aucheriana and was shown to possess proteasome inhibitory activity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Algeria 1 4%
United States 1 4%
Poland 1 4%
Unknown 24 89%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Researcher 4 15%
Student > Postgraduate 3 11%
Student > Bachelor 3 11%
Student > Ph. D. Student 3 11%
Other 6 22%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 5 19%
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 2 7%
Chemistry 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 3 11%
Unknown 8 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2014.
All research outputs
#5,308,084
of 17,563,644 outputs
Outputs from Cancer Cell International
#75
of 1,001 outputs
Outputs of similar age
#50,975
of 175,174 outputs
Outputs of similar age from Cancer Cell International
#1
of 1 outputs
Altmetric has tracked 17,563,644 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,001 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,174 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them