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Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors

Overview of attention for article published in Cancer Cell International, January 2013
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Mentioned by

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1 tweeter

Citations

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23 Dimensions

Readers on

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27 Mendeley
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Title
Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors
Published in
Cancer Cell International, January 2013
DOI 10.1186/1475-2867-13-82
Pubmed ID
Authors

Khaled Y Orabi, Mohamed S Abaza, Khalid A El Sayed, Ahmed Y Elnagar, Rajaa Al-Attiyah, Radhika P Guleri

Abstract

It has been shown that proteasome inhibition leads to growth arrest in the G1 phase of the cell cycle and/or induction of apoptosis. However, it was found that some of these inhibitors do not induce apoptosis in several human normal cell lines. This selective activity makes proteasome inhibition a promising target for new generation of anticancer drugs. Clinical validation of the proteasome, as a therapeutic target in oncology, has been provided by the dipeptide boronic acid derivative; bortezomib. Bortezomib has proven to be effective as a single agent in multiple myeloma and some forms of non-Hodgkin's lymphoma. Syringic acid (4-hydroxy-3,5-dimethoxybenzoic acid, 1), a known phenolic acid, was isolated from the methanol extract of Tamarix aucheriana and was shown to possess proteasome inhibitory activity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Algeria 1 4%
United States 1 4%
Poland 1 4%
Unknown 24 89%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Researcher 4 15%
Student > Postgraduate 3 11%
Student > Bachelor 3 11%
Student > Ph. D. Student 3 11%
Other 6 22%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 5 19%
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Chemistry 2 7%
Other 4 15%
Unknown 7 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2013.
All research outputs
#3,068,695
of 4,507,280 outputs
Outputs from Cancer Cell International
#119
of 226 outputs
Outputs of similar age
#66,260
of 97,737 outputs
Outputs of similar age from Cancer Cell International
#5
of 8 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 226 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,737 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.