↓ Skip to main content

Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, August 2013
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
21 Dimensions

Readers on

mendeley
28 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease
Published in
Arquivos de Neuro-Psiquiatria, August 2013
DOI 10.1590/0004-282x20130076
Pubmed ID
Authors

Marcela Augusta de Souza Pinhel, Caroline Leiko Sado, Gabriela dos Santos Longo, Michele Lima Gregorio, Gisele Sousa Amorim, Greiciane Maria da Silva Florim, Camila Montoro Mazeti, Denise Poltronieri Martins, Fabio de Nazare Oliveira, Marcelo Arruda Nakazone, Waldir Antonio Tognola, Doroteia Rossi Silva Souza

Abstract

Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the χ2 test for statistical analysis (p<0.05). The present and absence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1 and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared to controls (13%, p=0.014). This study suggests the association between PD and previous exposure to pesticides, whose effect may be enhanced in combination with null for GSTT1/GSTM1.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 18%
Student > Bachelor 5 18%
Student > Postgraduate 3 11%
Professor 3 11%
Student > Ph. D. Student 1 4%
Other 4 14%
Unknown 7 25%
Readers by discipline Count As %
Medicine and Dentistry 7 25%
Biochemistry, Genetics and Molecular Biology 5 18%
Nursing and Health Professions 2 7%
Neuroscience 2 7%
Psychology 1 4%
Other 2 7%
Unknown 9 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2013.
All research outputs
#10,033,318
of 12,539,922 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#370
of 526 outputs
Outputs of similar age
#110,138
of 160,367 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#12
of 17 outputs
Altmetric has tracked 12,539,922 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 526 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,367 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.