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Mendeley readers
| Title |
Complete pathologic response as a prognostic factor for squamous cell carcinoma of the oropharynx post-chemoradiotherapy
|
|---|---|
| Published in |
Brazilian Journal of Otorhinolaryngology, July 2015
|
| DOI | 10.1016/j.bjorl.2015.07.009 |
| Pubmed ID | |
| Authors |
Damila Cristina Trufelli, Leandro Luongo de Matos, Thaiana Aragão Santana, Fábio de Aquino Capelli, Jossi Ledo Kanda, Auro Del Giglio, Gilberto de Castro |
| Abstract |
Chemoradiotherapy for squamous cell carcinoma of the oropharynx (SCCO) provides good results for locoregional disease control, with high rates of complete clinical and pathologic responses, mainly in the neck. The aim of this study was to determine whether complete pathologic response after chemoradiotherapy is related to the prognosis of patients with SCCO. Data were prospectively extracted from clinical records of N2 and N3 SCCO patients submitted to a planned neck dissection after chemoradiotherapy. A total of 19 patients were evaluated. Half of patients obtained complete pathologic response in the neck. Distant or locoregional recurrence occurred in approximately 42% of patients, and 26% died. Statistical analysis showed an association between complete pathologic response and lower disease recurrence rate (77.8% vs. 20.8%; p=0.017) and greater overall survival (88.9% vs. 23.3%; p=0.049). The presence of a complete pathologic response after chemoradiotherapy positively influences the prognosis of patients with SCCO. |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 7% |
| Unknown | 13 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 29% |
| Student > Bachelor | 2 | 14% |
| Student > Doctoral Student | 1 | 7% |
| Librarian | 1 | 7% |
| Other | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 4 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 29% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
| Biochemistry, Genetics and Molecular Biology | 1 | 7% |
| Agricultural and Biological Sciences | 1 | 7% |
| Nursing and Health Professions | 1 | 7% |
| Other | 2 | 14% |
| Unknown | 4 | 29% |