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Complete pathologic response as a prognostic factor for squamous cell carcinoma of the oropharynx post-chemoradiotherapy

Overview of attention for article published in Brazilian Journal of Otorhinolaryngology, September 2015
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Title
Complete pathologic response as a prognostic factor for squamous cell carcinoma of the oropharynx post-chemoradiotherapy
Published in
Brazilian Journal of Otorhinolaryngology, September 2015
DOI 10.1016/j.bjorl.2015.07.009
Pubmed ID
Authors

Damila Cristina Trufelli, Leandro Luongo de Matos, Thaiana Aragão Santana, Fábio de Aquino Capelli, Jossi Ledo Kanda, Auro Del Giglio, Gilberto de Castro Junior

Abstract

Chemoradiotherapy for squamous cell carcinoma of the oropharynx (SCCO) provides good results for locoregional disease control, with high rates of complete clinical and pathologic responses, mainly in the neck. The aim of this study was to determine whether complete pathologic response after chemoradiotherapy is related to the prognosis of patients with SCCO. Data were prospectively extracted from clinical records of N2 and N3 SCCO patients submitted to a planned neck dissection after chemoradiotherapy. A total of 19 patients were evaluated. Half of patients obtained complete pathologic response in the neck. Distant or locoregional recurrence occurred in approximately 42% of patients, and 26% died. Statistical analysis showed an association between complete pathologic response and lower disease recurrence rate (77.8% vs. 20.8%; p=0.017) and greater overall survival (88.9% vs. 23.3%; p=0.049). The presence of a complete pathologic response after chemoradiotherapy positively influences the prognosis of patients with SCCO.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 31%
Student > Bachelor 2 15%
Librarian 1 8%
Student > Doctoral Student 1 8%
Researcher 1 8%
Other 0 0%
Unknown 4 31%
Readers by discipline Count As %
Medicine and Dentistry 4 31%
Agricultural and Biological Sciences 1 8%
Nursing and Health Professions 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Social Sciences 1 8%
Other 2 15%
Unknown 3 23%