@spence_jeffrey_ Yes, not consistent without recombination. We previously just used the expectation for finite n as the true values, see e.g., https://t.co/VcxClEaXuO. But what is n for pooled seq? Maybe expectation for n->infinity.
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@jrossibarra @a_hancoc The direction of the bias should depend on the exact criteria used for SNP calling, see e.g., Fig. 2 of https://t.co/MKLHAhru4N.
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Nielsen: B/c most genotype callers are too conservative w/calling genotypes, will bias est of Tajima's D (seln): http://t.co/fvI0kVrUlH
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Tajima's D simply explained by @mafnoor http://t.co/IN6ArO8o0I & pub calculating it w/ low coverage seq http://t.co/sY9KjGfSNf a nice combo.