Title |
The function of myostatin in the regulation of fat mass in mammals
|
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Published in |
Nutrition & Metabolism, March 2017
|
DOI | 10.1186/s12986-017-0179-1 |
Pubmed ID | |
Authors |
Bing Deng, Feng Zhang, Jianghui Wen, Shengqiang Ye, Lixia Wang, Yu Yang, Ping Gong, Siwen Jiang |
Abstract |
Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have found that MSTN is expressed in fat tissues and plays a key role in adipogenesis. Interestingly, MSTN can exert a dual function, either inhibiting or promoting adipogenesis, according to the situation. Due to its potential function in controlling body fat mass, MSTN has attracted the interest of researchers. In this review, we explore its function in regulating adipogenesis in mammals, including preadipocytes, multipotent stem cells and fat mass. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 91 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 18% |
Researcher | 10 | 11% |
Student > Bachelor | 10 | 11% |
Student > Master | 8 | 9% |
Professor | 6 | 7% |
Other | 10 | 11% |
Unknown | 31 | 34% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 22 | 24% |
Agricultural and Biological Sciences | 16 | 18% |
Medicine and Dentistry | 7 | 8% |
Veterinary Science and Veterinary Medicine | 5 | 5% |
Nursing and Health Professions | 2 | 2% |
Other | 9 | 10% |
Unknown | 30 | 33% |