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Control of mRNA stability contributes to low levels of nuclear poly(A) binding protein 1 (PABPN1) in skeletal muscle

Overview of attention for article published in Skeletal Muscle, October 2013
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4 X users

Citations

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33 Dimensions

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36 Mendeley
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Title
Control of mRNA stability contributes to low levels of nuclear poly(A) binding protein 1 (PABPN1) in skeletal muscle
Published in
Skeletal Muscle, October 2013
DOI 10.1186/2044-5040-3-23
Pubmed ID
Authors

Luciano H Apponi, Anita H Corbett, Grace K Pavlath

Abstract

The nuclear poly(A) binding protein 1 (PABPN1) is a ubiquitously expressed protein that plays critical roles at multiple steps in post-transcriptional regulation of gene expression. Short expansions of the polyalanine tract in the N-terminus of PABPN1 lead to oculopharyngeal muscular dystrophy (OPMD), which is an adult onset disease characterized by eyelid drooping, difficulty in swallowing, and weakness in the proximal limb muscles. Why alanine-expanded PABPN1 leads to muscle-specific pathology is unknown. Given the general function of PABPN1 in RNA metabolism, intrinsic characteristics of skeletal muscle may make this tissue susceptible to the effects of mutant PABPN1.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Italy 1 3%
Norway 1 3%
Unknown 33 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 25%
Researcher 8 22%
Student > Master 7 19%
Student > Bachelor 4 11%
Professor > Associate Professor 2 6%
Other 4 11%
Unknown 2 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 33%
Agricultural and Biological Sciences 12 33%
Medicine and Dentistry 5 14%
Nursing and Health Professions 1 3%
Psychology 1 3%
Other 1 3%
Unknown 4 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2013.
All research outputs
#12,883,635
of 22,725,280 outputs
Outputs from Skeletal Muscle
#249
of 360 outputs
Outputs of similar age
#104,383
of 207,105 outputs
Outputs of similar age from Skeletal Muscle
#3
of 6 outputs
Altmetric has tracked 22,725,280 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 360 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,105 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.