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A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

Overview of attention for article published in Science, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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145 Dimensions

Readers on

mendeley
319 Mendeley
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2 CiteULike
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Title
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
Published in
Science, March 2017
DOI 10.1126/science.aad8242
Pubmed ID
Authors

Jun Li, Michael S Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P Hubbard, Alvin J Y Ling, Luis A Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L Aravind, Clemens Steegborn, David A Sinclair

Abstract

DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD(+) (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD(+) to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate-ribose) polymerase], a critical DNA repair protein. As mice age and NAD(+) concentrations decline, DBC1 is increasingly bound to PARP1, causing DNA damage to accumulate, a process rapidly reversed by restoring the abundance of NAD(+) Thus, NAD(+) directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging.

X Demographics

X Demographics

The data shown below were collected from the profiles of 232 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 319 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Belgium 1 <1%
United Kingdom 1 <1%
Russia 1 <1%
Philippines 1 <1%
Unknown 313 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 60 19%
Researcher 56 18%
Student > Bachelor 45 14%
Student > Master 28 9%
Other 21 7%
Other 54 17%
Unknown 55 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 112 35%
Agricultural and Biological Sciences 56 18%
Medicine and Dentistry 26 8%
Chemistry 13 4%
Neuroscience 11 3%
Other 32 10%
Unknown 69 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1274. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#10,614
of 25,551,063 outputs
Outputs from Science
#557
of 83,109 outputs
Outputs of similar age
#165
of 323,296 outputs
Outputs of similar age from Science
#17
of 1,221 outputs
Altmetric has tracked 25,551,063 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,109 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,296 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,221 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.