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Structural and functional basis for RNA cleavage by Ire1

Overview of attention for article published in BMC Biology, July 2011
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1 tweeter

Citations

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Readers on

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106 Mendeley
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Title
Structural and functional basis for RNA cleavage by Ire1
Published in
BMC Biology, July 2011
DOI 10.1186/1741-7007-9-47
Pubmed ID
Authors

Alexei V Korennykh, Andrei A Korostelev, Pascal F Egea, Janet Finer-Moore, Robert M Stroud, Chao Zhang, Kevan M Shokat, Peter Walter

Abstract

The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1. The endoribonuclease (RNase) domain of Ire1 initiates a non-conventional mRNA splicing reaction, leading to the production of a transcription factor that controls UPR target genes. The mRNA splicing reaction is an obligatory step of Ire1 signaling, yet its mechanism has remained poorly understood due to the absence of substrate-bound crystal structures of Ire1, the lack of structural similarity between Ire1 and other RNases, and a scarcity of quantitative enzymological data. Here, we experimentally define the active site of Ire1 RNase and quantitatively evaluate the contribution of the key active site residues to catalysis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
France 1 <1%
Mexico 1 <1%
Germany 1 <1%
Unknown 101 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 30%
Researcher 22 21%
Student > Master 11 10%
Student > Bachelor 10 9%
Student > Doctoral Student 8 8%
Other 23 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 62 58%
Biochemistry, Genetics and Molecular Biology 24 23%
Chemistry 7 7%
Medicine and Dentistry 6 6%
Unspecified 3 3%
Other 4 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2011.
All research outputs
#10,969,521
of 12,378,406 outputs
Outputs from BMC Biology
#1,082
of 1,112 outputs
Outputs of similar age
#10,484,876
of 11,789,317 outputs
Outputs of similar age from BMC Biology
#1,082
of 1,112 outputs
Altmetric has tracked 12,378,406 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,112 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,112 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.