Title |
Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: study protocol for Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies (MR-IMPACT)
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Published in |
BMC Psychiatry, October 2013
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DOI | 10.1186/1471-244x-13-247 |
Pubmed ID | |
Authors |
Cindy C Hagan, Julia ME Graham, Barry Widmer, Rosemary J Holt, Cinly Ooi, Adrienne O van Nieuwenhuizen, Peter Fonagy, Shirley Reynolds, Mary Target, Raphael Kelvin, Paul O Wilkinson, Edward T Bullmore, Belinda R Lennox, Barbara J Sahakian, Ian Goodyer, John Suckling |
Abstract |
Major depressive disorders (MDD) are a debilitating and pervasive group of mental illnesses afflicting many millions of people resulting in the loss of 110 million working days and more than 2,500 suicides per annum. Adolescent MDD patients attending NHS clinics show high rates of recurrence into adult life. A meta-analysis of recent research shows that psychological treatments are not as efficacious as previously thought. Modest treatment outcomes of approximately 65% of cases responding suggest that aetiological and clinical heterogeneity may hamper the better use of existing therapies and discovery of more effective treatments. Information with respect to optimal treatment choice for individuals is lacking, with no validated biomarkers to aid therapeutic decision-making. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 2% |
Spain | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 207 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 43 | 20% |
Student > Ph. D. Student | 30 | 14% |
Student > Master | 25 | 12% |
Student > Bachelor | 22 | 10% |
Student > Doctoral Student | 16 | 8% |
Other | 33 | 15% |
Unknown | 44 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 75 | 35% |
Medicine and Dentistry | 42 | 20% |
Neuroscience | 11 | 5% |
Nursing and Health Professions | 6 | 3% |
Social Sciences | 6 | 3% |
Other | 21 | 10% |
Unknown | 52 | 24% |