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Discovery and refinement of loci associated with lipid levels

Overview of attention for article published in Nature Genetics, October 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
11 news outlets
blogs
4 blogs
policy
1 policy source
twitter
25 tweeters
patent
1 patent
wikipedia
1 Wikipedia page

Citations

dimensions_citation
1350 Dimensions

Readers on

mendeley
881 Mendeley
citeulike
7 CiteULike
Title
Discovery and refinement of loci associated with lipid levels
Published in
Nature Genetics, October 2013
DOI 10.1038/ng.2797
Pubmed ID
Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 881 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 10 1%
United Kingdom 10 1%
Canada 2 <1%
Switzerland 2 <1%
Mexico 2 <1%
Sweden 2 <1%
Finland 2 <1%
Egypt 1 <1%
Netherlands 1 <1%
Other 10 1%
Unknown 839 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 229 26%
Researcher 217 25%
Student > Master 82 9%
Professor > Associate Professor 51 6%
Student > Bachelor 51 6%
Other 193 22%
Unknown 58 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 237 27%
Medicine and Dentistry 206 23%
Biochemistry, Genetics and Molecular Biology 199 23%
Computer Science 19 2%
Psychology 15 2%
Other 90 10%
Unknown 115 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 128. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2019.
All research outputs
#124,484
of 13,996,779 outputs
Outputs from Nature Genetics
#361
of 6,259 outputs
Outputs of similar age
#1,571
of 166,889 outputs
Outputs of similar age from Nature Genetics
#13
of 86 outputs
Altmetric has tracked 13,996,779 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,259 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,889 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.