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Complete genome sequencing and antibiotics biosynthesis pathways analysis of Streptomyces lydicus 103

Overview of attention for article published in Scientific Reports, March 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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12 X users
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1 Facebook page

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70 Mendeley
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Title
Complete genome sequencing and antibiotics biosynthesis pathways analysis of Streptomyces lydicus 103
Published in
Scientific Reports, March 2017
DOI 10.1038/srep44786
Pubmed ID
Authors

Nan Jia, Ming-Zhu Ding, Hao Luo, Feng Gao, Ying-Jin Yuan

Abstract

More and more new natural products have been found in Streptomyces species, which become the significant resource for antibiotics production. Among them, Streptomyces lydicus has been known as its ability of streptolydigin biosynthesis. Herein, we present the genome analysis of S. lydicus based on the complete genome sequencing. The circular chromosome of S. lydicus 103 comprises 8,201,357 base pairs with average GC content 72.22%. With the aid of KEGG analysis, we found that S. lydicus 103 can transfer propanoate to succinate, glutamine or glutamate to 2-oxoglutarate, CO2 and L-glutamate to ammonia, which are conducive to the the supply of amino acids. S. lydicus 103 encodes acyl-CoA thioesterase II that takes part in biosynthesis of unsaturated fatty acids, and harbors the complete biosynthesis pathways of lysine, valine, leucine, phenylalanine, tyrosine and isoleucine. Furthermore, a total of 27 putative gene clusters have been predicted to be involved in secondary metabolism, including biosynthesis of streptolydigin, erythromycin, mannopeptimycin, ectoine and desferrioxamine B. Comparative genome analysis of S. lydicus 103 will help us deeply understand its metabolic pathways, which is essential for enhancing the antibiotic production through metabolic engineering.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 70 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 23%
Student > Bachelor 9 13%
Researcher 8 11%
Student > Master 7 10%
Student > Doctoral Student 4 6%
Other 7 10%
Unknown 19 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 27%
Agricultural and Biological Sciences 18 26%
Chemistry 5 7%
Immunology and Microbiology 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 3 4%
Unknown 22 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2017.
All research outputs
#4,850,987
of 24,383,935 outputs
Outputs from Scientific Reports
#37,073
of 132,670 outputs
Outputs of similar age
#81,990
of 313,520 outputs
Outputs of similar age from Scientific Reports
#1,358
of 4,483 outputs
Altmetric has tracked 24,383,935 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 132,670 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,520 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 4,483 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.