Title |
Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer
|
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Published in |
Cochrane database of systematic reviews, October 2013
|
DOI | 10.1002/14651858.cd008944.pub2 |
Pubmed ID | |
Authors |
Sebastiaan L Knijnenburg, Renée L Mulder, Antoinette YN Schouten‐Van Meeteren, Arend Bökenkamp, Hester Blufpand, Eline van Dulmen‐den Broeder, Margreet A Veening, Leontien CM Kremer, Monique WM Jaspers |
Abstract |
Great improvements in diagnostics and treatment for malignant disease in childhood have led to a major increase in survival. However, childhood cancer survivors (CCS) are at great risk for developing adverse effects caused by multimodal treatment for their malignancy. Nephrotoxicity is one of these known (acute) side effects of several treatments, including cisplatin, carboplatin, ifosfamide, radiotherapy and nephrectomy, and can cause glomerular filtration rate impairment, proteinuria, tubulopathy and hypertension. However, evidence about the long-term effects of these treatments on renal function remains inconclusive. To reduce the number of (long-term) nephrotoxic events in CCS, it is important to know the risk of, and risk factors for, early and late renal adverse effects, so that ultimately treatment and screening protocols can be adjusted. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 38% |
Netherlands | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Ireland | 1 | <1% |
Unknown | 196 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 33 | 17% |
Researcher | 28 | 14% |
Student > Bachelor | 25 | 13% |
Student > Ph. D. Student | 19 | 10% |
Student > Postgraduate | 18 | 9% |
Other | 34 | 17% |
Unknown | 41 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 88 | 44% |
Nursing and Health Professions | 19 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
Social Sciences | 7 | 4% |
Agricultural and Biological Sciences | 6 | 3% |
Other | 20 | 10% |
Unknown | 49 | 25% |