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Aging Not Gender Is Associated with High Atazanavir Plasma Concentrations in Asian HIV-Infected Patients.

Overview of attention for article published in AIDS Research and Human Retroviruses, October 2013
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  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

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4 tweeters

Citations

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5 Dimensions

Readers on

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11 Mendeley
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Title
Aging Not Gender Is Associated with High Atazanavir Plasma Concentrations in Asian HIV-Infected Patients.
Published in
AIDS Research and Human Retroviruses, October 2013
DOI 10.1089/aid.2013.0069
Pubmed ID
Authors

Anchalee Avihingsanon, Stephen J Kerr, Baralee Punyawudho, Jasper van der Lugt, Meena Gorowara, Jintanat Ananworanich, Joep M A Lange, David A Cooper, Praphan Phanuphak, David M Burger, Kiat Ruxrungtham, Avihingsanon A, Kerr SJ, Punyawudho B, van der Lugt J, Gorowara M, Ananworanich J, Lange JM, Cooper DA, Phanuphak P, Burger DM, Ruxrungtham K, Stephen J. Kerr, Joep M.A. Lange, David A. Cooper, David M. Burger, Avihingsanon, Anchalee, Kerr, Stephen J., Punyawudho, Baralee, van der Lugt, Jasper, Gorowara, Meena, Ananworanich, Jintanat, Lange, Joep M.A., Cooper, David A., Phanuphak, Praphan, Burger, David M., Ruxrungtham, Kiat

Abstract

Physiological effects of aging make the older population more susceptible to adverse drug events and drug-drug interactions. We evaluated the impact of aging and gender on the pharmacokinetics (PK) of atazanavir/ritonavir (ATV/r) 300/100 mg once daily (qd) in 22 well-suppressed HIV-infected patients. This was a 24-h intensive PK study. Subjects were HIV-1-infected adults aged ≥18 years with HIV RNA <50 copies/ml and treated with ATV/r 300/100 mg once daily plus two nucleoside reverse transcriptase inhibitors (NRTIs) for at least 2 weeks. Atazanavir and ritonavir plasma concentrations were measured by validated high-performance liquid chromatography (HPLC). Plasma PK parameters were calculated using noncompartmental methods. Since 50% of the patients were older than 42 years, age 42 was selected as the cut-off point for the older (>42 years) group. Gender, weight, duration of ATV/r therapy, and proportion treated with tenofovir disoproxil fumarate (TDF)-containing regimens did not differ between both groups. Patients from the aging group had a reduced creatinine clearance (91 versus 76 ml/min). The older group had a higher atazanavir exposure with median AUC(0-24) 71.2 vs. 53.1 mg·h/liter, C(max) 8.5 vs. 5.5 mg/liter, and C(trough) 1.17 vs. 0.78 mg/liter, and slower apparent clearance (3.5 vs. 4.8 liter/h). Ten patients (91%) from the older group and 36% from the younger group had ATV C(trough) levels higher than the proposed upper limit for toxicity of 0.85 mg/liter. Females had a lower body weight (BW) (46 versus 63 kg) than the males, but atazanavir concentrations in females were greater. However, in multivariate analysis, older age was the only significant predictor for higher atazanavir concentrations. Parameter estimate for age and atazanavir AUC after adjusting for gender and BW was 2.17 (95% CI 1.01-3.33). That is, for every year increase in age, AUC increases by approximately 2 mg·h/liter. Age seems to be an important factor influencing atazanavir pharmacokinetics. Patients from the aging group appeared to have higher atazanavir exposure compared to the younger group. Further PK explorations of ATV in the extremely aged population are warranted.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 27%
Student > Ph. D. Student 1 9%
Student > Master 1 9%
Student > Postgraduate 1 9%
Other 1 9%
Other 4 36%
Readers by discipline Count As %
Medicine and Dentistry 3 27%
Biochemistry, Genetics and Molecular Biology 3 27%
Unspecified 3 27%
Pharmacology, Toxicology and Pharmaceutical Science 2 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2013.
All research outputs
#2,164,995
of 4,866,789 outputs
Outputs from AIDS Research and Human Retroviruses
#188
of 650 outputs
Outputs of similar age
#41,337
of 104,583 outputs
Outputs of similar age from AIDS Research and Human Retroviruses
#3
of 17 outputs
Altmetric has tracked 4,866,789 research outputs across all sources so far. This one has received more attention than most of these and is in the 54th percentile.
So far Altmetric has tracked 650 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,583 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.