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Blood levels of vitamin D and early stage breast cancer prognosis: a systematic review and meta-analysis

Overview of attention for article published in Breast Cancer Research and Treatment, October 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
9 tweeters
facebook
1 Facebook page
video
1 video uploader

Citations

dimensions_citation
52 Dimensions

Readers on

mendeley
52 Mendeley
citeulike
1 CiteULike
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Title
Blood levels of vitamin D and early stage breast cancer prognosis: a systematic review and meta-analysis
Published in
Breast Cancer Research and Treatment, October 2013
DOI 10.1007/s10549-013-2713-9
Pubmed ID
Authors

April A. N. Rose, Christine Elser, Marguerite Ennis, Pamela J. Goodwin

Abstract

Vitamin D regulates expression of genes important in development and progression of breast cancer. The association of vitamin D with breast cancer outcomes among breast cancer patients is controversial. We conducted a systematic review and meta-analysis of this association in early stage breast cancer outcome. We searched MEDLINE (1982-May 1, 2013), the American Society of Clinical Oncology (2009-2012), and the San Antonio Breast Cancer Symposium (2010-2012) for abstracts, using the following keywords: "breast cancer" and "prognosis" or "survival", and "vitamin D" or" calcitriol" to identify studies reporting the associations of blood vitamin D levels (drawn close to diagnosis) with breast cancer outcomes. Meta-analyses were performed using an inverse-variance weighted fixed-effects model with Stata Version 12. Eight studies including 5,691 patients were identified. Vitamin D deficiency was variably categorized across studies; a median of 36.8 % of patients were classified as deficient. Low vitamin D levels were associated with a pooled hazard ratio of 2.13 (95 % CI 1.64-2.78) and 1.76 (95 % CIs 1.35-2.30) for recurrence (six studies) and death (four studies), respectively, with no evidence of significant heterogeneity across studies. There was potential evidence of a publication bias in studies examining associations with death (but not in those examining associations with recurrence). These findings support an association of low levels of vitamin D with increased risk of recurrence and death in early stage breast cancer patients. Given the observational nature of the included studies, it cannot be concluded that this association is causal. Further research is warranted to investigate the potential beneficial effects of vitamin D in breast cancer.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
Denmark 1 2%
Lebanon 1 2%
Unknown 49 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Master 8 15%
Student > Ph. D. Student 8 15%
Unspecified 6 12%
Student > Bachelor 5 10%
Other 15 29%
Readers by discipline Count As %
Medicine and Dentistry 24 46%
Unspecified 11 21%
Agricultural and Biological Sciences 9 17%
Mathematics 2 4%
Nursing and Health Professions 2 4%
Other 4 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2019.
All research outputs
#727,655
of 13,527,331 outputs
Outputs from Breast Cancer Research and Treatment
#112
of 3,290 outputs
Outputs of similar age
#10,439
of 165,982 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#4
of 51 outputs
Altmetric has tracked 13,527,331 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,290 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,982 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.