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The structure of Zika virus NS5 reveals a conserved domain conformation

Overview of attention for article published in Nature Communications, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Citations

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86 Mendeley
Title
The structure of Zika virus NS5 reveals a conserved domain conformation
Published in
Nature Communications, March 2017
DOI 10.1038/ncomms14763
Pubmed ID
Authors

Boxiao Wang, Xiao-Feng Tan, Stephanie Thurmond, Zhi-Min Zhang, Asher Lin, Rong Hai, Jikui Song

Abstract

The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alternative conformations of flavivirus NS5 proteins. The activity of this NS5 protein is verified through a de novo RdRp assay on a subgenomic ZIKV RNA template. Importantly, our structural analysis leads to the identification of a potential drug-binding site of ZIKV NS5, which might facilitate the development of novel antivirals for ZIKV.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 86 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 21%
Unspecified 14 16%
Researcher 13 15%
Student > Master 13 15%
Student > Ph. D. Student 12 14%
Other 16 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 24 28%
Unspecified 15 17%
Agricultural and Biological Sciences 14 16%
Immunology and Microbiology 9 10%
Chemistry 8 9%
Other 16 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 505. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2017.
All research outputs
#10,785
of 9,777,221 outputs
Outputs from Nature Communications
#166
of 16,468 outputs
Outputs of similar age
#798
of 261,498 outputs
Outputs of similar age from Nature Communications
#18
of 818 outputs
Altmetric has tracked 9,777,221 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,468 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 46.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,498 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 818 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.