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Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial

Overview of attention for article published in Arthritis Research & Therapy, March 2013
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Title
Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial
Published in
Arthritis Research & Therapy, March 2013
DOI 10.1186/ar4205
Pubmed ID
Authors

Danilo ML Prado, Fabiana B Benatti, Ana L de Sá-Pinto, Ana P Hayashi, Bruno Gualano, Rosa MR Pereira, Adriana ME Sallum, Eloisa Bonfá, Clovis A Silva, Hamilton Roschel

Abstract

INTRODUCTION: Exercise training has emerged as a promising therapeutic strategy to counteract physical dysfunction in adult systemic lupus erythematosus. However, no longitudinal studies have evaluated the effects of an exercise training program in childhood-onset systemic lupus erythematosus (C-SLE) patients. The objective was to evaluate the safety and the efficacy of a supervised aerobic training program in improving the cardiorespiratory capacity in C-SLE patients. METHODS: Nineteen physically inactive C-SLE patients were randomly assigned into two groups: trained (TR, n = 10, supervised moderate-intensity aerobic exercise program) and non-trained (NT, n = 9). Gender-, body mass index (BMI)- and age-matched healthy children were recruited as controls (C, n = 10) for baseline (PRE) measurements only. C-SLE patients were assessed at PRE and after 12 weeks of training (POST). Main measurements included exercise tolerance and cardiorespiratory measurements in response to a maximal exercise (that is, peak VO2, chronotropic reserve (CR), and the heart rate recovery (ΔHRR) (that is, the difference between HR at peak exercise and at both the first (ΔHRR1) and second (ΔHRR2) minutes of recovery after exercise). RESULTS: The C-SLE NT patients did not present changes in any of the cardiorespiratory parameters at POST (P > 0.05). In contrast, the exercise training program was effective in promoting significant increases in time-to-exhaustion (P = 0.01; ES = 1.07), peak speed (P = 0.01; ES = 1.08), peak VO2 (P = 0.04; ES = 0.86), CR (P = 0.06; ES = 0.83), and in ΔHRR1 and ΔHRR2 (P = 0.003; ES = 1.29 and P = 0.0008; ES = 1.36, respectively) in the C-SLE TR when compared with the NT group. Moreover, cardiorespiratory parameters were comparable between C-SLE TR patients and C subjects after the exercise training intervention, as evidenced by the ANOVA analysis (P > 0.05, TR vs. C). SLEDAI-2K scores remained stable throughout the study. CONCLUSION: A 3-month aerobic exercise training was safe and capable of ameliorating the cardiorespiratory capacity and the autonomic function in C-SLE patients. TRIAL REGISTRATION: NCT01515163.

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Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
Unknown 132 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 25 19%
Student > Master 21 16%
Student > Ph. D. Student 14 10%
Researcher 12 9%
Student > Postgraduate 8 6%
Other 23 17%
Unknown 31 23%
Readers by discipline Count As %
Medicine and Dentistry 37 28%
Sports and Recreations 20 15%
Nursing and Health Professions 14 10%
Biochemistry, Genetics and Molecular Biology 8 6%
Agricultural and Biological Sciences 4 3%
Other 13 10%
Unknown 38 28%