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Antigenic Drift in H5N1 Avian Influenza Virus in Poultry Is Driven by Mutations in Major Antigenic Sites of the Hemagglutinin Molecule Analogous to Those for Human Influenza Virus

Overview of attention for article published in Journal of Virology, July 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Citations

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88 Dimensions

Readers on

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86 Mendeley
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1 CiteULike
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Title
Antigenic Drift in H5N1 Avian Influenza Virus in Poultry Is Driven by Mutations in Major Antigenic Sites of the Hemagglutinin Molecule Analogous to Those for Human Influenza Virus
Published in
Journal of Virology, July 2011
DOI 10.1128/jvi.02403-10
Pubmed ID
Authors

G. Cattoli, A. Milani, N. Temperton, B. Zecchin, A. Buratin, E. Molesti, M. M. Aly, A. Arafa, I. Capua

Abstract

H5N1 highly pathogenic avian influenza virus has been endemic in poultry in Egypt since 2008, notwithstanding the implementation of mass vaccination and culling of infected birds. Extensive circulation of the virus has resulted in a progressive genetic evolution and an antigenic drift. In poultry, the occurrence of antigenic drift in avian influenza viruses is less well documented and the mechanisms remain to be clarified. To test the hypothesis that H5N1 antigenic drift is driven by mechanisms similar to type A influenza viruses in humans, we generated reassortant viruses, by reverse genetics, that harbored molecular changes identified in genetically divergent viruses circulating in the vaccinated population. Parental and reassortant phenotype viruses were antigenically analyzed by hemagglutination inhibition (HI) test and microneutralization (MN) assay. The results of the study indicate that the antigenic drift of H5N1 in poultry is driven by multiple mutations primarily occurring in major antigenic sites at the receptor binding subdomain, similarly to what has been described for human influenza H1 and H3 subtype viruses.

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Bangladesh 1 1%
Italy 1 1%
Kenya 1 1%
United Kingdom 1 1%
Denmark 1 1%
Unknown 81 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 23%
Student > Ph. D. Student 19 22%
Student > Master 11 13%
Student > Bachelor 7 8%
Student > Doctoral Student 5 6%
Other 13 15%
Unknown 11 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 35%
Veterinary Science and Veterinary Medicine 10 12%
Biochemistry, Genetics and Molecular Biology 10 12%
Medicine and Dentistry 10 12%
Computer Science 4 5%
Other 9 10%
Unknown 13 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2018.
All research outputs
#2,431,113
of 14,480,032 outputs
Outputs from Journal of Virology
#1,995
of 13,898 outputs
Outputs of similar age
#2,322,972
of 13,666,675 outputs
Outputs of similar age from Journal of Virology
#1,969
of 13,775 outputs
Altmetric has tracked 14,480,032 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,898 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 13,666,675 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 13,775 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.