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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites
|
|---|---|
| Published in |
Science, March 2017
|
| DOI | 10.1126/science.aal1807 |
| Pubmed ID | |
| Authors |
M Dawidowski, L Emmanouilidis, V C Kalel, K Tripsianes, K Schorpp, K Hadian, M Kaiser, P Mäser, M Kolonko, S Tanghe, A Rodriguez, W Schliebs, R Erdmann, M Sattler, G M Popowicz |
| Abstract |
The parasitic protists of the Trypanosoma genus infect humans and domestic mammals, causing severe mortality and huge economic losses. The most threatening trypanosomiasis is Chagas disease, affecting up to 12 million people in the Americas. We report a way to selectively kill Trypanosoma by blocking glycosomal/peroxisomal import that depends on the PEX14-PEX5 protein-protein interaction. We developed small molecules that efficiently disrupt the PEX14-PEX5 interaction. This results in mislocalization of glycosomal enzymes, causing metabolic catastrophe, and it kills the parasite. High-resolution x-ray structures and nuclear magnetic resonance data enabled the efficient design of inhibitors with trypanocidal activities comparable to approved medications. These results identify PEX14 as an "Achilles' heel" of the Trypanosoma suitable for the development of new therapies against trypanosomiases and provide the structural basis for their development. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 10 | 28% |
| United States | 5 | 14% |
| Brazil | 3 | 8% |
| Germany | 2 | 6% |
| France | 1 | 3% |
| India | 1 | 3% |
| Argentina | 1 | 3% |
| Czechia | 1 | 3% |
| Unknown | 12 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 61% |
| Scientists | 9 | 25% |
| Science communicators (journalists, bloggers, editors) | 5 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 191 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 23% |
| Researcher | 39 | 20% |
| Student > Master | 22 | 11% |
| Student > Bachelor | 20 | 10% |
| Professor > Associate Professor | 8 | 4% |
| Other | 19 | 10% |
| Unknown | 40 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 57 | 30% |
| Agricultural and Biological Sciences | 27 | 14% |
| Chemistry | 25 | 13% |
| Immunology and Microbiology | 9 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
| Other | 19 | 10% |
| Unknown | 48 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 118. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2021.
All research outputs
#357,766
of 25,506,250 outputs
Outputs from Science
#9,367
of 83,066 outputs
Outputs of similar age
#7,537
of 324,218 outputs
Outputs of similar age from Science
#183
of 1,203 outputs
Altmetric has tracked 25,506,250 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,066 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,218 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,203 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.