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Inhibitory signalling to the Arp2/3 complex steers cell migration

Overview of attention for article published in Nature, October 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

9 tweeters
2 patents
1 peer review site
1 research highlight platform


99 Dimensions

Readers on

365 Mendeley
Inhibitory signalling to the Arp2/3 complex steers cell migration
Published in
Nature, October 2013
DOI 10.1038/nature12611
Pubmed ID

Irene Dang, Roman Gorelik, Carla Sousa-Blin, Emmanuel Derivery, Christophe Guérin, Joern Linkner, Maria Nemethova, Julien G. Dumortier, Florence A. Giger, Tamara A. Chipysheva, Valeria D. Ermilova, Sophie Vacher, Valérie Campanacci, Isaline Herrada, Anne-Gaelle Planson, Susan Fetics, Véronique Henriot, Violaine David, Ksenia Oguievetskaia, Goran Lakisic, Fabienne Pierre, Anika Steffen, Adeline Boyreau, Nadine Peyriéras, Klemens Rottner, Sophie Zinn-Justin, Jacqueline Cherfils, Ivan Bièche, Antonina Y. Alexandrova, Nicolas B. David, J. Victor Small, Jan Faix, Laurent Blanchoin, Alexis Gautreau


Cell migration requires the generation of branched actin networks that power the protrusion of the plasma membrane in lamellipodia. The actin-related proteins 2 and 3 (Arp2/3) complex is the molecular machine that nucleates these branched actin networks. This machine is activated at the leading edge of migrating cells by Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein (WAVE, also known as SCAR). The WAVE complex is itself directly activated by the small GTPase Rac, which induces lamellipodia. However, how cells regulate the directionality of migration is poorly understood. Here we identify a new protein, Arpin, that inhibits the Arp2/3 complex in vitro, and show that Rac signalling recruits and activates Arpin at the lamellipodial tip, like WAVE. Consistently, after depletion of the inhibitory Arpin, lamellipodia protrude faster and cells migrate faster. A major role of this inhibitory circuit, however, is to control directional persistence of migration. Indeed, Arpin depletion in both mammalian cells and Dictyostelium discoideum amoeba resulted in straighter trajectories, whereas Arpin microinjection in fish keratocytes, one of the most persistent systems of cell migration, induced these cells to turn. The coexistence of the Rac-Arpin-Arp2/3 inhibitory circuit with the Rac-WAVE-Arp2/3 activatory circuit can account for this conserved role of Arpin in steering cell migration.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 365 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 2%
Germany 6 2%
United Kingdom 5 1%
France 4 1%
Finland 2 <1%
Japan 2 <1%
Switzerland 1 <1%
Netherlands 1 <1%
Portugal 1 <1%
Other 4 1%
Unknown 331 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 111 30%
Student > Ph. D. Student 92 25%
Student > Master 37 10%
Professor > Associate Professor 28 8%
Student > Bachelor 25 7%
Other 72 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 202 55%
Biochemistry, Genetics and Molecular Biology 76 21%
Unspecified 20 5%
Physics and Astronomy 16 4%
Medicine and Dentistry 12 3%
Other 39 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2015.
All research outputs
of 11,339,688 outputs
Outputs from Nature
of 58,961 outputs
Outputs of similar age
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Outputs of similar age from Nature
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Altmetric has tracked 11,339,688 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,961 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 70.7. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 153,590 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 1,042 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.