| Chapter title |
MicroRNAs in Human Cancer.
|
|---|---|
| Chapter number | 1 |
| Book title |
MicroRNA Cancer Regulation
|
| Published in |
Advances in experimental medicine and biology, December 2012
|
| DOI | 10.1007/978-94-007-5590-1_1 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-075589-5, 978-9-40-075590-1
|
| Authors |
Farazi TA, Hoell JI, Morozov P, Tuschl T, Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov, Thomas Tuschl |
| Editors |
Ulf Schmitz, Olaf Wolkenhauer, Julio Vera |
| Abstract |
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20-23-nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the translation and stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and invasion. miRNA targeting is initiated through specific base-pairing interactions between the 5' end ("seed" region) of the miRNA and sites within coding and untranslated regions (UTRs) of mRNAs; target sites in the 3' UTR lead to more effective mRNA destabilization. Since miRNAs frequently target hundreds of mRNAs, miRNA regulatory pathways are complex. To provide a critical overview of miRNA dysregulation in cancer, we first discuss the methods currently available for studying the role of miRNAs in cancer and then review miRNA genomic organization, biogenesis, and mechanism of target recognition, examining how these processes are altered in tumorigenesis. Given the critical role miRNAs play in tumorigenesis processes and their disease specific expression, they hold potential as therapeutic targets and novel biomarkers. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Brazil | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 1% |
| Unknown | 82 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 19% |
| Student > Ph. D. Student | 15 | 18% |
| Student > Bachelor | 11 | 13% |
| Student > Master | 10 | 12% |
| Student > Postgraduate | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 17 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 24% |
| Agricultural and Biological Sciences | 17 | 20% |
| Medicine and Dentistry | 12 | 14% |
| Computer Science | 5 | 6% |
| Engineering | 3 | 4% |
| Other | 10 | 12% |
| Unknown | 16 | 19% |