Title |
A phase I study on combined therapy with proton-beam radiotherapy and in situ tumor vaccination for locally advanced recurrent hepatocellular carcinoma
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Published in |
Radiation Oncology, October 2013
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DOI | 10.1186/1748-717x-8-239 |
Pubmed ID | |
Authors |
Masato Abei, Toshiyuki Okumura, Kuniaki Fukuda, Takayuki Hashimoto, Masahiro Araki, Kazunori Ishige, Ichinosuke Hyodo, Ayae Kanemoto, Haruko Numajiri, Masashi Mizumoto, Takeji Sakae, Hideyuki Sakurai, Junko Zenkoh, Gerelchuluun Ariungerel, Yu Sogo, Atsuo Ito, Tadao Ohno, Koji Tsuboi |
Abstract |
Proton-beam radiotherapy (PBT) has been shown to be effective to hepatocellular carcinoma (HCC) as a nonsurgical local treatment option. However, HCC still remains as one of the most difficult cancers to be cured because of frequent recurrences. Thus, methods to inhibit the recurrence need to be explored. To prevent the HCC recurrence, we here report on a prospective phase I study of 'in situ' tumor vaccination using CalTUMP, a newly developed immunoadjuvant consisting of BCG extract bound to hydroxyapatite and microparticulated tuberculin, following local PBT for HCC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 2% |
France | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 54 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 14% |
Student > Bachelor | 8 | 14% |
Student > Master | 6 | 11% |
Student > Ph. D. Student | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Other | 11 | 19% |
Unknown | 15 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 33% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Engineering | 3 | 5% |
Immunology and Microbiology | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Other | 13 | 23% |
Unknown | 14 | 25% |