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HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation

Overview of attention for article published in BMC Infectious Diseases, March 2017
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Title
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation
Published in
BMC Infectious Diseases, March 2017
DOI 10.1186/s12879-017-2334-8
Pubmed ID
Authors

Malene Hove-Skovsgaard, Julie Christine Gaardbo, Lilian Kolte, Kamilla Winding, Ingebjørg Seljeflot, Asbjørn Svardal, Rolf Kristian Berge, Jan Gerstoft, Henrik Ullum, Marius Trøseid, Susanne Dam Nielsen

Abstract

Increased incidence of cardiovascular diseases (CVD) in both HIV infection and type 2 diabetes (T2D) compared to the general population has been described. Little is known about the combined effect of HIV infection and T2D on inflammation and endothelial function, both of which may contribute to elevated risk of CVD. Cross-sectional study including 50 HIV-infected persons on combination anti-retroviral therapy (cART), with HIV RNA <200 copies/mL (n = 25 with T2D (HIV + T2D+), n = 25 without T2D (HIV + T2D-)) and 50 uninfected persons (n = 22 with T2D (HIV-T2D+) and n = 28 without T2D (HIV-T2D-)). Groups were matched on age and sex. High sensitive C-reactive protein (hsCRP) was used to determine inflammation (cut-off 3 mg/L). The marker of endothelial dysfunction asymmetric dimethylarginine (ADMA) was measured using high performance liquid chromatography. Trimethylamine-N-oxide (TMAO), a microbiota-dependent, pro-atherogenic marker was measured using stable isotope dilution LC/MS/MS. The percentage of HIV + T2D+, HIV + T2D-, HIV-T2D+, and HIV-T2D- with hsCRP above cut-off was 50%, 19%, 47%, and 11%, respectively. HIV + T2D+ had elevated ADMA (0.67 μM (0.63-0.72) compared to HIV + T2D- (0.60 μM (0.57-0.64) p = 0.017), HIV-T2D+ (0.57 μM (0.51-63) p = 0.008), and HIV-T2D- (0.55 μM (0.52-0.58) p < 0.001). No differences in TMAO between groups were found. However, a positive correlation between ADMA and TMAO was found in the total population (rs = 0.32, p = 0.001), which was mainly driven by a close correlation in HIV + T2D+ (rs = 0.63, p = 0.001). Elevated inflammation and evidence of endothelial dysfunction was found in HIV-infected persons with T2D. The effect on inflammation was mainly driven by T2D, while both HIV infection and T2D may contribute to endothelial dysfunction. Whether gut microbiota is a contributing factor to this remains to be determined.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 29%
Student > Doctoral Student 3 9%
Lecturer 2 6%
Researcher 2 6%
Student > Bachelor 2 6%
Other 5 15%
Unknown 10 29%
Readers by discipline Count As %
Medicine and Dentistry 5 15%
Agricultural and Biological Sciences 5 15%
Immunology and Microbiology 4 12%
Nursing and Health Professions 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 4 12%
Unknown 11 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2017.
All research outputs
#7,132,300
of 9,339,536 outputs
Outputs from BMC Infectious Diseases
#2,934
of 4,069 outputs
Outputs of similar age
#188,473
of 260,803 outputs
Outputs of similar age from BMC Infectious Diseases
#85
of 131 outputs
Altmetric has tracked 9,339,536 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,069 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.