Title |
Utility of the REBA MTB-rifa® assay for rapid detection of rifampicin resistant Mycobacterium Tuberculosis
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Published in |
BMC Infectious Diseases, October 2013
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DOI | 10.1186/1471-2334-13-478 |
Pubmed ID | |
Authors |
Eunjin Cho, Isdore Chola Shamputa, Hyun-Kyung Kwak, Jiim Lee, Myungsun Lee, Soohee Hwang, Doosoo Jeon, Cheon Tae Kim, Sangnae Cho, Laura E Via, Clifton E Barry, Jong Seok Lee |
Abstract |
Drug-resistant tuberculosis (TB), including resistance to both rifampicin (RIF) and isoniazid (INH) referred to as multidrug-resistant tuberculosis (MDR-TB), has become an increasing global threat in recent years. Effective management of patients infected with MDR-TB strains requires identifying such patients by performing conventional drug-susceptibility testing (DST) on bacteria isolated from sputum, a process that can take up to 2 months. This delay in diagnosis can result in worsening and continued transmission of MDR-TB. Molecular methods that rely upon nucleic acid amplification of specific alleles known to be associated with resistance to specific drugs have been helpful in shortening the time to detect drug resistant TB. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 17% |
Researcher | 11 | 17% |
Student > Postgraduate | 10 | 15% |
Other | 7 | 11% |
Student > Master | 6 | 9% |
Other | 13 | 20% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 33% |
Immunology and Microbiology | 7 | 11% |
Agricultural and Biological Sciences | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Engineering | 4 | 6% |
Other | 10 | 15% |
Unknown | 13 | 20% |