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ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma

Overview of attention for article published in Cancer Research, March 2017
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  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

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5 tweeters

Citations

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44 Dimensions

Readers on

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57 Mendeley
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Title
ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma
Published in
Cancer Research, March 2017
DOI 10.1158/0008-5472.can-16-3398
Pubmed ID
Authors

Anna Schmitt, Gero Knittel, Daniela Welcker, Tsun-Po Yang, Julie George, Michael Nowak, Uschi Leeser, Reinhard Büttner, Sven Perner, Martin Peifer, Hans Christian Reinhardt

Abstract

Defects in maintaining genome integrity are a hallmark of cancer. The DNA damage response kinase ATM is frequently mutated in human cancer, but the significance of these events to chemotherapeutic efficacy has not been examined deeply in whole organism models. Here we demonstrate that bi-allelic Atm deletion in mouse models of Kras-mutant lung adenocarcinoma does not affect cisplatin responses. In marked contrast, Atm-deficient tumors displayed an enhanced response to the topoisomerase-II poison etoposide. Moreover, Atm-deficient cells and tumors were sensitive to the PARP inhibitor olaparib. This actionable molecular addiction to functional PARP1 signaling was preserved in models that were proficient or deficient in p53, resembling standard or high-risk genetic constellations, respectively. Atm deficiency also markedly enhanced sensitivity to the ATR inhibitor VE-822. Taken together, our results provide a functional rationale to profile human tumors for disabling ATM mutations, particularly given their impact on PARP1 and ATR inhibitors.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 23%
Researcher 9 16%
Student > Bachelor 8 14%
Student > Master 5 9%
Student > Postgraduate 4 7%
Other 8 14%
Unknown 10 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 44%
Medicine and Dentistry 9 16%
Agricultural and Biological Sciences 7 12%
Chemical Engineering 1 2%
Chemistry 1 2%
Other 2 4%
Unknown 12 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2017.
All research outputs
#7,109,662
of 14,011,199 outputs
Outputs from Cancer Research
#8,873
of 13,430 outputs
Outputs of similar age
#103,562
of 263,259 outputs
Outputs of similar age from Cancer Research
#52
of 142 outputs
Altmetric has tracked 14,011,199 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,430 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 142 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.