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Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases

Overview of attention for article published in Cochrane database of systematic reviews, October 2007
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
18 news outlets
blogs
5 blogs
policy
1 policy source
twitter
6 tweeters
wikipedia
5 Wikipedia pages

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
127 Mendeley
citeulike
1 CiteULike
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Title
Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Published in
Cochrane database of systematic reviews, October 2007
DOI 10.1002/14651858.cd003620.pub3
Pubmed ID
Authors

Andrea Rambaldi, Bradly P Jacobs, Christian Gluud

Abstract

Alcohol and hepatotoxic viruses cause the majority of liver diseases. Randomised clinical trials have assessed whether extracts of milk thistle, Silybum marianum (L) Gaertneri, have any effect in patients with alcoholic and/or hepatitis B or C virus liver diseases. To assess the beneficial and harmful effects of milk thistle or milk thistle constituents versus placebo or no intervention in patients with alcoholic liver disease and/or viral liver diseases (hepatitis B and hepatitis C). The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and full text searches were combined (July 2007). Manufacturers and researchers in the field were contacted. Only randomised clinical trials in patients with alcoholic and/or hepatitis B or C virus liver diseases (acute and chronic) were included. Interventions encompassed milk thistle at any dose or duration versus placebo or no intervention. The trials could be double blind, single blind, or unblinded. The trials could be unpublished or published and no language limitations were applied. The primary outcome measure was mortality. Binary outcomes are reported as relative risks (RR) with 95% confidence interval (CI). Subgroup analyses were performed with regard to methodological quality. Eighteen randomised clinical trials assessed milk thistle in 1088 patients with alcoholic and/or hepatitis B or C virus liver diseases. The methodological quality was low: only 28.6% of the trials reported high methodological quality characteristics. Milk thistle versus placebo or no intervention had no significant effect on mortality (RR 0.78, 95% CI 0.53 to 1.15), complications of liver disease (RR 0.95, 95% CI 0.83 to 1.09), or liver histology. Liver-related mortality was significantly reduced by milk thistle in all trials (RR 0.50, 95% CI 0.29 to 0.88), but not in high-quality trials (RR 0.57, 95% CI 0.28 to 1.19). Milk thistle was not associated with a significantly increased risk of adverse events (RR 0.83, 95% CI 0.46 to 1.50). Our results question the beneficial effects of milk thistle for patients with alcoholic and/or hepatitis B or C virus liver diseases and highlight the lack of high-quality evidence to support this intervention. Adequately conducted and reported randomised clinical trials on milk thistle versus placebo are needed.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Italy 1 <1%
Canada 1 <1%
South Africa 1 <1%
Unknown 123 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 32 25%
Student > Master 19 15%
Researcher 17 13%
Other 12 9%
Student > Ph. D. Student 8 6%
Other 22 17%
Unknown 17 13%
Readers by discipline Count As %
Medicine and Dentistry 52 41%
Nursing and Health Professions 16 13%
Pharmacology, Toxicology and Pharmaceutical Science 10 8%
Biochemistry, Genetics and Molecular Biology 5 4%
Agricultural and Biological Sciences 5 4%
Other 12 9%
Unknown 27 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 169. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2019.
All research outputs
#108,206
of 15,456,048 outputs
Outputs from Cochrane database of systematic reviews
#216
of 11,188 outputs
Outputs of similar age
#104,363
of 14,510,452 outputs
Outputs of similar age from Cochrane database of systematic reviews
#207
of 9,659 outputs
Altmetric has tracked 15,456,048 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,188 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 14,510,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 9,659 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.