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Effect of Peroral Administration of Chromium on Insulin Signaling Pathway in Skeletal Muscle Tissue of Holstein Calves

Overview of attention for article published in Biological Trace Element Research, April 2017
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Title
Effect of Peroral Administration of Chromium on Insulin Signaling Pathway in Skeletal Muscle Tissue of Holstein Calves
Published in
Biological Trace Element Research, April 2017
DOI 10.1007/s12011-017-1007-1
Pubmed ID
Authors

Ljubomir Jovanović, Marija Pantelić, Radiša Prodanović, Ivan Vujanac, Miloje Đurić, Snežana Tepavčević, Sanja Vranješ-Đurić, Goran Korićanac, Danijela Kirovski

Abstract

The objective of this study was to investigate the effects of peroral administration of chromium-enriched yeast on glucose tolerance in Holstein calves, assessed by insulin signaling pathway molecule determination and intravenous glucose tolerance test (IVGTT). Twenty-four Holstein calves, aged 1 month, were chosen for the study and divided into two groups: the PoCr group (n = 12) that perorally received 0.04 mg of Cr/kg of body mass daily, for 70 days, and the NCr group (n = 12) that received no chromium supplementation. Skeletal tissue samples from each calf were obtained on day 0 and day 70 of the experiment. Chromium supplementation increased protein content of the insulin β-subunit receptor, phosphorylation of insulin receptor substrate 1 at Tyrosine 632, phosphorylation of Akt at Serine 473, glucose transporter-4, and AMP-activated protein kinase in skeletal muscle tissue, while phosphorylation of insulin receptor substrate 1 at Serine 307 was not affected by chromium treatment. Results obtained during IVGTT, which was conducted on days 0, 30, 50, and 70, suggested an increased insulin sensitivity and, consequently, a better utilization of glucose in the PoCr group. Lower basal concentrations of glucose and insulin in the PoCr group on days 30 and 70 were also obtained. Our results indicate that chromium supplementation improves glucose utilization in calves by enhancing insulin intracellular signaling in the skeletal muscle tissue.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 12%
Professor > Associate Professor 2 12%
Student > Ph. D. Student 2 12%
Researcher 2 12%
Librarian 1 6%
Other 1 6%
Unknown 7 41%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Nursing and Health Professions 1 6%
Sports and Recreations 1 6%
Medicine and Dentistry 1 6%
Other 1 6%
Unknown 11 65%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2017.
All research outputs
#8,419,593
of 9,652,674 outputs
Outputs from Biological Trace Element Research
#834
of 1,060 outputs
Outputs of similar age
#220,671
of 262,388 outputs
Outputs of similar age from Biological Trace Element Research
#16
of 26 outputs
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So far Altmetric has tracked 1,060 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.