Title |
Personalizing and targeting therapy for COPD – the role of molecular and clinical biomarkers
|
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Published in |
Expert Review of Respiratory Medicine, January 2014
|
DOI | 10.1586/17476348.2013.842468 |
Pubmed ID | |
Authors |
Felicia Goh, Janet G Shaw, Santiyagu M Savarimuthu Francis, Annalicia Vaughan, Leanne Morrison, Vandana Relan, Henry M Marshall, Annette G Dent, Phoebe E O’Hare, Amy Hsiao, Rayleen V Bowman, Kwun M Fong, Ian A Yang |
Abstract |
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by persistent airflow limitation. It is the third leading cause of death worldwide, and there are currently no curative strategies for this disease. Many factors contribute to COPD susceptibility, progression and exacerbations. These include cigarette smoking, environmental and occupational pollutants, respiratory infections and comorbidities. As the clinical phenotypes of COPD are so variable, it has been difficult to devise an individualized treatment plan for patients with this complex chronic disease. This review will highlight how potential clinical, inflammatory, genomic and epigenomic biomarkers for COPD could be used to personalize treatment, leading to improved disease management and prevention for our patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 50% |
France | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Unknown | 33 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 26% |
Student > Master | 5 | 15% |
Student > Bachelor | 5 | 15% |
Student > Ph. D. Student | 4 | 12% |
Other | 3 | 9% |
Other | 6 | 18% |
Unknown | 2 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 41% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
Sports and Recreations | 3 | 9% |
Computer Science | 2 | 6% |
Other | 5 | 15% |
Unknown | 4 | 12% |