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IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid arthritis patients

Overview of attention for article published in Arthritis Research & Therapy, October 2013
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Title
IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid arthritis patients
Published in
Arthritis Research & Therapy, October 2013
DOI 10.1186/ar4357
Pubmed ID
Authors

Lingxiao Xu, Xiaoke Feng, Wenfeng Tan, Weijuan Gu, Dunming Guo, Miaojia Zhang, Fang Wang

Abstract

We previously reported that IL-29, a newly described member of interferon (IFN) family, was overexpressed in blood and synovium of rheumatoid arthritis (RA) patients and triggered proinflammatory cytokine IL-6 and IL-8 mRNA expression in RA synovial fibroblasts (RA-FLS). This suggests that IL-29 has an important role in synovial inflammation. Toll-like receptors (TLRs) also activate RA-FLS to produce inflammatory mediators including tumor necrosis factor α (TNF-α) and IL-1β in RA-FLS. Since the TLR family plays an early role in the innate immune response and the subsequent induction of the adaptive immune response, we hypothesize that IL-29 interacts with TLRs in RA inflammation. This study aimed to investigate the effect of IL-29 on TLR-mediated proinflammatory cytokine production in RA-FLS.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 16%
Student > Ph. D. Student 5 14%
Student > Bachelor 4 11%
Other 4 11%
Student > Doctoral Student 3 8%
Other 8 22%
Unknown 7 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 19%
Immunology and Microbiology 7 19%
Medicine and Dentistry 5 14%
Biochemistry, Genetics and Molecular Biology 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 5 14%
Unknown 8 22%