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Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity

Overview of attention for article published in Malaria Journal, April 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

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1 news outlet
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13 X users
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1 Facebook page

Citations

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46 Dimensions

Readers on

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121 Mendeley
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Title
Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity
Published in
Malaria Journal, April 2017
DOI 10.1186/s12936-017-1796-x
Pubmed ID
Authors

Temitope W. Ademolue, Yaw Aniweh, Kwadwo A. Kusi, Gordon A. Awandare

Abstract

In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear. Since inflammatory responses to parasite infection contribute to the clinical manifestation of malaria, this study investigated inflammatory cytokine responses in children with malaria from areas of different transmission intensities (ranging from low to high). Blood samples were obtained from children confirmed with malaria at community hospitals in three areas with differing transmission intensities. Cytokine levels were assessed using the Luminex(®)-based magnetic bead array system, and levels were compared across sites using appropriate statistical tests. The relative contributions of age, gender, parasitaemia and transmission intensity on cytokine levels were investigated using multivariate regression analysis. Parasite density increased with increasing transmission intensity in children presenting to hospital with symptomatic malaria, indicating that the parasitaemia threshold for clinical malaria increases with increasing transmission intensity. Furthermore, levels of pro-inflammatory cytokines, including tumour necrosis factor alpha (TNF-α), interferon-gamma (IFN-γ), interleukin (IL)-1β, IL-2, IL-6, IL-8, and IL-12, decreased with increasing transmission intensity, and correlated significantly with parasitaemia levels in the low transmission area but not in high transmission areas. Similarly, levels of anti-inflammatory cytokines, including IL-4, IL-7, IL-10 and IL-13, decreased with increasing transmission intensity, with IL-10 showing strong correlation with parasitaemia levels in the low transmission area. Multiple linear regression analyses revealed that transmission intensity was a stronger predictor of cytokine levels than age, gender and parasitaemia. Taken together, the data demonstrate a strong relationship between the prevailing transmission intensity, parasitaemia levels and the magnitude of inflammatory responses induced during clinical malaria.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Brazil 1 <1%
Unknown 119 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 14%
Researcher 16 13%
Student > Ph. D. Student 16 13%
Student > Bachelor 12 10%
Student > Postgraduate 8 7%
Other 16 13%
Unknown 36 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 14%
Agricultural and Biological Sciences 15 12%
Medicine and Dentistry 15 12%
Immunology and Microbiology 14 12%
Nursing and Health Professions 5 4%
Other 13 11%
Unknown 42 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2020.
All research outputs
#1,704,036
of 24,400,706 outputs
Outputs from Malaria Journal
#292
of 5,827 outputs
Outputs of similar age
#33,470
of 314,089 outputs
Outputs of similar age from Malaria Journal
#13
of 136 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,827 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,089 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.