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The role of vitamin C in the treatment of pain: new insights

Overview of attention for article published in Journal of Translational Medicine, April 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

twitter
45 tweeters
facebook
14 Facebook pages
googleplus
1 Google+ user
video
1 video uploader

Citations

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34 Dimensions

Readers on

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140 Mendeley
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Title
The role of vitamin C in the treatment of pain: new insights
Published in
Journal of Translational Medicine, April 2017
DOI 10.1186/s12967-017-1179-7
Pubmed ID
Authors

Anitra C. Carr, Cate McCall

Abstract

The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermore, accumulating evidence indicates that vitamin C administration can exhibit analgesic properties in some clinical conditions. The prevalence of hypovitaminosis C and vitamin C deficiency is high in various patient groups, such as surgical/trauma, infectious diseases and cancer patients. A number of recent clinical studies have shown that vitamin C administration to patients with chronic regional pain syndrome decreases their symptoms. Acute herpetic and post-herpetic neuralgia is also diminished with high dose vitamin C administration. Furthermore, cancer-related pain is decreased with high dose vitamin C, contributing to enhanced patient quality of life. A number of mechanisms have been proposed for vitamin C's analgesic properties. Herein we propose a novel analgesic mechanism for vitamin C; as a cofactor for the biosynthesis of amidated opioid peptides. It is well established that vitamin C participates in the amidation of peptides, through acting as a cofactor for peptidyl-glycine α-amidating monooxygenase, the only enzyme known to amidate the carboxy terminal residue of neuropeptides and peptide hormones. Support for our proposed mechanism comes from studies which show a decreased requirement for opioid analgesics in surgical and cancer patients administered high dose vitamin C. Overall, vitamin C appears to be a safe and effective adjunctive therapy for acute and chronic pain relief in specific patient groups.

Twitter Demographics

The data shown below were collected from the profiles of 45 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 <1%
Australia 1 <1%
Unknown 138 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 25 18%
Other 19 14%
Student > Master 19 14%
Researcher 15 11%
Student > Postgraduate 11 8%
Other 26 19%
Unknown 25 18%
Readers by discipline Count As %
Medicine and Dentistry 49 35%
Nursing and Health Professions 14 10%
Biochemistry, Genetics and Molecular Biology 13 9%
Immunology and Microbiology 7 5%
Pharmacology, Toxicology and Pharmaceutical Science 7 5%
Other 21 15%
Unknown 29 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2020.
All research outputs
#593,516
of 15,314,925 outputs
Outputs from Journal of Translational Medicine
#97
of 2,883 outputs
Outputs of similar age
#18,920
of 267,180 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 1 outputs
Altmetric has tracked 15,314,925 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,883 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,180 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them