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Neonatal necrotizing enterocolitis rat model attenuated by a remote ischemic preconditioning in the pregnant

Overview of attention for article published in Acta Cirurgica Brasileira, March 2017
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Title
Neonatal necrotizing enterocolitis rat model attenuated by a remote ischemic preconditioning in the pregnant
Published in
Acta Cirurgica Brasileira, March 2017
DOI 10.1590/s0102-865020170030000008
Pubmed ID
Authors

Rúdnei de Oliveira Luciano Gomes, Ricardo Artigiani Neto, José de Freitas Guimarães Neto, Adriana Porto Nunes, Edna Frasson de Souza Montero, José Luiz Martins

Abstract

To evaluate the effect of remote ischemic preconditioning (r-IPC) administered to pregnant rats, in the ileum of newborn rats subjected to hypoxia and reoxygenation. We used three pregnant rats and their newborn rats distributed in three groups: 1) Control (C) - Newborn rats born from a pregnant rat which did not undergo any intervention; 2) Hypoxia-Reoxygenation (H/R) - Newborn rats born from a pregnant rat which did not undergo any intervention, and were subjected to hypoxia-reoxygenation; 3) Remote Ischemic Preconditioning (r-IPC) - newborn rats born from a pregnant rat which was subjected to remote ischemic preconditioning twenty-four hours before giving birth and the newborn rats were subjected to hypoxia-reoxygenation. Segments of ileum were prepared for histological analysis by HE and immunohistochemistry by the Ki67 to evaluate cell proliferation, crypt depth and villus height and evaluation of apoptosis by cleaved caspase-3. The intensity of the lesions was lower in the r-IPC than in the H/R group, showing significant difference (p<0.01). The r-IPC group showed a higher proliferative activity compared to the H/R group (p<0.01), with deeper crypts (r-IPC > H/R - p < 0.05), and higher villi, showing significant difference (r-IPC > H/R - (p <0.01). The occurrence of apoptosis in the H/R group was lower in comparison to groups C and r-IPC, with significant difference (H/R < r-IPC; p<0.05). The remote ischemic preconditioning applied to the pregnant rat protected the ileum of newborn rats subjected to hypoxia and reoxygenation, with decreased intensity of the lesions in the ileum mucosa and preservation of proliferative activity, keeping the villus height and crypt depth similar to group C.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 31%
Student > Doctoral Student 2 15%
Student > Master 2 15%
Lecturer 1 8%
Professor > Associate Professor 1 8%
Other 1 8%
Unknown 2 15%
Readers by discipline Count As %
Medicine and Dentistry 6 46%
Nursing and Health Professions 2 15%
Social Sciences 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Engineering 1 8%
Other 0 0%
Unknown 2 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2017.
All research outputs
#8,450,316
of 9,689,121 outputs
Outputs from Acta Cirurgica Brasileira
#42
of 75 outputs
Outputs of similar age
#221,173
of 263,536 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#1
of 2 outputs
Altmetric has tracked 9,689,121 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 75 research outputs from this source. They receive a mean Attention Score of 1.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,536 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them