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Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation

Overview of attention for article published in Molecular Therapy, March 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

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41 Dimensions

Readers on

mendeley
70 Mendeley
Title
Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation
Published in
Molecular Therapy, March 2014
DOI 10.1038/mt.2013.261
Pubmed ID
Authors

Aideen E Ryan, Paul Lohan, Lisa O'Flynn, Oliver Treacy, Xizhe Chen, Cynthia Coleman, Georgina Shaw, Mary Murphy, Frank Barry, Matthew D Griffin, Thomas Ritter

Abstract

Allogeneic mesenchymal stem cells (allo-MSCs) have potent regenerative and immunosuppressive potential and are being investigated as a therapy for osteoarthritis; however, little is known about the immunological changes that occur in allo-MSCs after ex vivo induced or in vivo differentiation. Three-dimensional chondrogenic differentiation was induced in an alginate matrix, which served to immobilize and potentially protect MSCs at the site of implantation. We show that allogeneic differentiated MSCs lost the ability to inhibit T-cell proliferation in vitro, in association with reduced nitric oxide and prostaglandin E2 secretion. Differentiation altered immunogenicity as evidenced by induced proliferation of allogeneic T cells and increased susceptibility to cytotoxic lysis by allo-specific T cells. Undifferentiated or differentiated allo-MSCs were implanted subcutaneously, with and without alginate encapsulation. Increased CD3(+) and CD68(+) infiltration was evident in differentiated and splenocyte encapsulated implants only. Without encapsulation, increased local memory T-cell responses were detectable in recipients of undifferentiated and differentiated MSCs; however, only differentiated MSCs induced systemic memory T-cell responses. In recipients of encapsulated allogeneic cells, only differentiated allo-MSCs induced memory T-cell responses locally and systemically. Systemic alloimmune responses to differentiated MSCs indicate immunogenicity regardless of alginate encapsulation and may require immunosuppressive therapy for therapeutic use.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
France 1 1%
Ireland 1 1%
Italy 1 1%
United Kingdom 1 1%
Unknown 65 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 23%
Researcher 16 23%
Student > Ph. D. Student 13 19%
Student > Bachelor 5 7%
Student > Doctoral Student 4 6%
Other 11 16%
Unknown 5 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 27%
Medicine and Dentistry 18 26%
Biochemistry, Genetics and Molecular Biology 9 13%
Engineering 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 10 14%
Unknown 7 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2013.
All research outputs
#1,632,196
of 12,060,716 outputs
Outputs from Molecular Therapy
#748
of 2,976 outputs
Outputs of similar age
#22,458
of 163,054 outputs
Outputs of similar age from Molecular Therapy
#7
of 28 outputs
Altmetric has tracked 12,060,716 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,976 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.