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The ability of lipopolysaccharide (LPS) of Pasteurella multocida B:2 to induce clinical and pathological lesions in the nervous system of buffalo calves following experimental inoculation

Overview of attention for article published in Microbial Pathogenesis, March 2017
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Title
The ability of lipopolysaccharide (LPS) of Pasteurella multocida B:2 to induce clinical and pathological lesions in the nervous system of buffalo calves following experimental inoculation
Published in
Microbial Pathogenesis, March 2017
DOI 10.1016/j.micpath.2017.01.031
Pubmed ID
Authors

Ali Dhiaa Marza, Faez Firdaus Jesse Abdullah, Ihsan Muneer Ahmed, Eric Lim Teik Chung, Hayder Hamzah Ibrahim, Mohd Zamri-Saad, Abdul Rahman Omar, Md Zuki Abu Bakar, Abdul Aziz Saharee, Abdul Wahid Haron, Mohammed Jwaid Alwan, Mohd Azmi Mohd Lila

Abstract

Lipopolysaccharide (LPS) of P. multocida B:2, a causative agent of haemorrhagic septicaemia (HS) in cattle and buffaloes, is considered as the main virulence factor and contribute in the pathogenesis of the disease. Recent studies provided evidences about the involvement of the nervous system in pathogenesis of HS. However, the role of P. multocida B:2 immunogens, especially the LPS is still uncovered. Therefore, this study was designed to investigate the role of P. multocida B:2 LPS to induce pathological changes in the nervous system. Nine eight-month-old, clinically healthy buffalo calves were used and distributed into three groups. Calves of Group 1 and 2 were inoculated orally and intravenously with 10 ml of LPS broth extract represent 1 × 10(12) cfu/ml of P. multocida B:2, respectively, while calves of Group 3 were inoculated orally with 10 ml of phosphate buffer saline as a control. Significant differences were found in the mean scores for clinical signs, post mortem and histopathological changes especially in Group 2, which mainly affect different anatomic regions of the nervous system, mainly the brain. On the other hand, lower scores have been recorded for clinical signs, gross and histopathological changes in Group 1. These results provide for the first time strong evidence about the ability of P. multocida B:2 LPS to cross the blood brain barrier and induce pathological changes in the nervous system of the affected buffalo calves.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 24%
Professor 3 18%
Lecturer > Senior Lecturer 2 12%
Student > Ph. D. Student 2 12%
Student > Master 2 12%
Other 1 6%
Unknown 3 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 29%
Biochemistry, Genetics and Molecular Biology 2 12%
Medicine and Dentistry 2 12%
Veterinary Science and Veterinary Medicine 1 6%
Immunology and Microbiology 1 6%
Other 1 6%
Unknown 5 29%