Title |
Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action
|
---|---|
Published in |
Molecular Autism, November 2013
|
DOI | 10.1186/2040-2392-4-45 |
Pubmed ID | |
Authors |
Thomas A Lanz, Edward Guilmette, Mark M Gosink, James E Fischer, Lawrence W Fitzgerald, Diane T Stephenson, Mathew T Pletcher |
Abstract |
Austism spectrum disorder (ASD) is a heterogeneous behavioral disorder or condition characterized by severe impairment of social engagement and the presence of repetitive activities. The molecular etiology of ASD is still largely unknown despite a strong genetic component. Part of the difficulty in turning genetics into disease mechanisms and potentially new therapeutics is the sheer number and diversity of the genes that have been associated with ASD and ASD symptoms. The goal of this work is to use shRNA-generated models of genetic defects proposed as causative for ASD to identify the common pathways that might explain how they produce a core clinical disability. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Unknown | 98 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 20 | 20% |
Student > Ph. D. Student | 19 | 19% |
Student > Master | 10 | 10% |
Student > Bachelor | 10 | 10% |
Other | 5 | 5% |
Other | 20 | 20% |
Unknown | 17 | 17% |
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Agricultural and Biological Sciences | 25 | 25% |
Biochemistry, Genetics and Molecular Biology | 16 | 16% |
Neuroscience | 13 | 13% |
Medicine and Dentistry | 12 | 12% |
Engineering | 4 | 4% |
Other | 12 | 12% |
Unknown | 19 | 19% |