Report for: Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain

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Title	Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain
Published in	Acta Neuropathologica Communications, August 2013
DOI	10.1186/2051-5960-1-54
Pubmed ID	24252707
Authors	Ayaho Dan, Muneaki Takahashi, Masami Masuda-Suzukake, Fuyuki Kametani, Takashi Nonaka, Hiromi Kondo, Haruhiko Akiyama, Takao Arai, David MA Mann, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama, Masato Hasegawa
Abstract	Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why different tau isoforms accumulate in different diseases and how they induce abnormal filamentous structures and pathologies. Two tau isoform-specific antibodies, RD3 and RD4, are widely used for immunohistochemical and biochemical studies of tau species in diseased brains.

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Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	42	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	15	36%
Student > Doctoral Student	5	12%
Student > Bachelor	4	10%
Other	4	10%
Professor	4	10%
Other	5	12%
Unknown	5	12%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	9	21%
Agricultural and Biological Sciences	8	19%
Chemistry	7	17%
Medicine and Dentistry	6	14%
Neuroscience	4	10%
Other	2	5%
Unknown	6	14%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2022.

All research outputs

#7,227,170

of 22,842,950 outputs

Outputs from Acta Neuropathologica Communications

#943

of 1,375 outputs

Outputs of similar age

#63,604

of 199,042 outputs

Outputs of similar age from Acta Neuropathologica Communications

of 18 outputs

Altmetric has tracked 22,842,950 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.

So far Altmetric has tracked 1,375 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,042 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.

We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.

Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain

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Attention Score in Context