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Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase

Overview of attention for article published in Virology Journal, January 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 2,386)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
13 news outlets
blogs
2 blogs
twitter
33 tweeters
facebook
2 Facebook pages
wikipedia
1 Wikipedia page
googleplus
8 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
135 Dimensions

Readers on

mendeley
166 Mendeley
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Title
Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase
Published in
Virology Journal, January 2013
DOI 10.1186/1743-422x-10-321
Pubmed ID
Authors

Miriam Cohen, Xing-Quan Zhang, Hooman P Senaati, Hui-Wen Chen, Nissi M Varki, Robert T Schooley, Pascal Gagneux

Abstract

Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and viral release from cultured human airway epithelial cells. The role of NA in viral exit is well established: it releases budding virions by cleaving Sias from glycoconjugates on infected cells and progeny virions. The role of NA in viral entry remains unclear. Host respiratory epithelia secrete a mucus layer rich in heavily sialylated glycoproteins; these could inhibit viral entry by mimicking sialylated receptors on the cell surface. It has been suggested that NA allows influenza to penetrate the mucus by cleaving these sialylated decoys, but the exact mechanism is not yet established.

Twitter Demographics

The data shown below were collected from the profiles of 33 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Japan 1 <1%
China 1 <1%
Unknown 161 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 28%
Student > Bachelor 30 18%
Researcher 23 14%
Student > Master 17 10%
Professor > Associate Professor 8 5%
Other 24 14%
Unknown 17 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 27%
Biochemistry, Genetics and Molecular Biology 30 18%
Immunology and Microbiology 24 14%
Chemistry 15 9%
Medicine and Dentistry 13 8%
Other 19 11%
Unknown 21 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 140. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2018.
All research outputs
#135,942
of 15,405,287 outputs
Outputs from Virology Journal
#9
of 2,386 outputs
Outputs of similar age
#1,864
of 260,982 outputs
Outputs of similar age from Virology Journal
#2
of 208 outputs
Altmetric has tracked 15,405,287 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,386 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,982 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 208 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.