Title |
Clinical and multimodal biomarker correlates of ADNI neuropathological findings
|
---|---|
Published in |
Acta Neuropathologica Communications, October 2013
|
DOI | 10.1186/2051-5960-1-65 |
Pubmed ID | |
Authors |
Jon B Toledo, Nigel J Cairns, Xiao Da, Kewei Chen, Deborah Carter, Adam Fleisher, Erin Householder, Napatkamon Ayutyanont, Auttawut Roontiva, Robert J Bauer, Paul Eisen, Leslie M Shaw, Christos Davatzikos, Michael W Weiner, Eric M Reiman, John C Morris, John Q Trojanowski, the Alzheimer’s Disease Neuroimaging Initiative |
Abstract |
Autopsy series commonly report a high percentage of coincident pathologies in demented patients, including patients with a clinical diagnosis of dementia of the Alzheimer type (DAT). However many clinical and biomarker studies report cases with a single neurodegenerative disease. We examined multimodal biomarker correlates of the consecutive series of the first 22 Alzheimer's Disease Neuroimaging Initiative autopsies. Clinical data, neuropsychological measures, cerebrospinal fluid Aβ, total and phosphorylated tau and α-synuclein and MRI and FDG-PET scans. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 3 | 30% |
Japan | 1 | 10% |
United States | 1 | 10% |
Unknown | 5 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 90% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Netherlands | 1 | <1% |
United States | 1 | <1% |
Canada | 1 | <1% |
Unknown | 149 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 29 | 19% |
Researcher | 25 | 16% |
Student > Master | 13 | 8% |
Professor | 11 | 7% |
Student > Postgraduate | 10 | 7% |
Other | 32 | 21% |
Unknown | 33 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 34 | 22% |
Neuroscience | 25 | 16% |
Psychology | 15 | 10% |
Agricultural and Biological Sciences | 10 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 3% |
Other | 24 | 16% |
Unknown | 40 | 26% |