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Detection of hepatitis C virus (HCV) negative strand RNA and NS3 protein in peripheral blood mononuclear cells (PBMC): CD3+, CD14+ and CD19+

Overview of attention for article published in Virology Journal, November 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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8 X users
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1 Facebook page
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1 Google+ user

Citations

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39 Dimensions

Readers on

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25 Mendeley
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Title
Detection of hepatitis C virus (HCV) negative strand RNA and NS3 protein in peripheral blood mononuclear cells (PBMC): CD3+, CD14+ and CD19+
Published in
Virology Journal, November 2013
DOI 10.1186/1743-422x-10-346
Pubmed ID
Authors

Agnieszka Pawełczyk, Natalia Kubisa, Joanna Jabłońska, Iwona Bukowska-Ośko, Kamile Caraballo Cortes, Maria Fic, Tomasz Laskus, Marek Radkowski

Abstract

Although hepatitis C virus (HCV) is primarily hepatotropic, markers of HCV replication were detected in peripheral blood mononuclear cells (PBMC) as well as in ex vivo collected tissues and organs. Specific strains of HCV were found to be capable to infect cells of the immune system: T and B cells and monocytes/macrophages as well as cell lines in vitro. The direct invasion of cells of the immune system by the virus may be responsible for extrahepatic consequences of HCV infection: cryoglobulinemia and non-Hodgkin's lymphoma.The aim of the present study was to determine the prevalence of markers of HCV infection: negative strand HCV RNA and non-structural NS3 protein in PBMC subpopulations: CD3+, CD14+ and CD19+. The presence of virus and the proportion of affected cells within a particular PBMC fraction could indicate a principal target cell susceptible for HCV.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 24%
Researcher 4 16%
Student > Bachelor 3 12%
Student > Master 3 12%
Student > Postgraduate 2 8%
Other 4 16%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 24%
Medicine and Dentistry 6 24%
Biochemistry, Genetics and Molecular Biology 3 12%
Immunology and Microbiology 3 12%
Computer Science 1 4%
Other 1 4%
Unknown 5 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2013.
All research outputs
#4,855,751
of 23,592,647 outputs
Outputs from Virology Journal
#489
of 3,124 outputs
Outputs of similar age
#57,090
of 309,964 outputs
Outputs of similar age from Virology Journal
#15
of 58 outputs
Altmetric has tracked 23,592,647 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,124 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.8. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,964 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.