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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential Effects of Antibiotic Therapy on the Structure and Function of Human Gut Microbiota
|
|---|---|
| Published in |
PLOS ONE, November 2013
|
| DOI | 10.1371/journal.pone.0080201 |
| Pubmed ID | |
| Authors |
Ana Elena Pérez-Cobas, Alejandro Artacho, Henrik Knecht, María Loreto Ferrús, Anette Friedrichs, Stephan J. Ott, Andrés Moya, Amparo Latorre, María José Gosalbes |
| Abstract |
The human intestinal microbiota performs many essential functions for the host. Antimicrobial agents, such as antibiotics (AB), are also known to disturb microbial community equilibrium, thereby having an impact on human physiology. While an increasing number of studies investigate the effects of AB usage on changes in human gut microbiota biodiversity, its functional effects are still poorly understood. We performed a follow-up study to explore the effect of ABs with different modes of action on human gut microbiota composition and function. Four individuals were treated with different antibiotics and samples were taken before, during and after the AB course for all of them. Changes in the total and in the active (growing) microbiota as well as the functional changes were addressed by 16S rRNA gene and metagenomic 454-based pyrosequencing approaches. We have found that the class of antibiotic, particularly its antimicrobial effect and mode of action, played an important role in modulating the gut microbiota composition and function. Furthermore, analysis of the resistome suggested that oscillatory dynamics are not only due to antibiotic-target resistance, but also to fluctuations in the surviving bacterial community. Our results indicated that the effect of AB on the human gut microbiota relates to the interaction of several factors, principally the properties of the antimicrobial agent, and the structure, functions and resistance genes of the microbial community. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 35% |
| United Kingdom | 5 | 19% |
| Spain | 2 | 8% |
| Canada | 1 | 4% |
| Venezuela, Bolivarian Republic of | 1 | 4% |
| Netherlands | 1 | 4% |
| Cameroon | 1 | 4% |
| Unknown | 6 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 54% |
| Scientists | 8 | 31% |
| Practitioners (doctors, other healthcare professionals) | 4 | 15% |
Mendeley readers
The data shown below were compiled from readership statistics for 334 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Spain | 2 | <1% |
| Ghana | 1 | <1% |
| Hungary | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 322 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 67 | 20% |
| Researcher | 48 | 14% |
| Student > Bachelor | 47 | 14% |
| Student > Master | 45 | 13% |
| Student > Postgraduate | 19 | 6% |
| Other | 45 | 13% |
| Unknown | 63 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 75 | 22% |
| Medicine and Dentistry | 55 | 16% |
| Biochemistry, Genetics and Molecular Biology | 48 | 14% |
| Immunology and Microbiology | 39 | 12% |
| Nursing and Health Professions | 7 | 2% |
| Other | 31 | 9% |
| Unknown | 79 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2019.
All research outputs
#2,089,028
of 25,711,518 outputs
Outputs from PLOS ONE
#25,380
of 224,015 outputs
Outputs of similar age
#22,572
of 319,545 outputs
Outputs of similar age from PLOS ONE
#671
of 5,216 outputs
Altmetric has tracked 25,711,518 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 224,015 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,545 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 5,216 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.