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Impaired Noradrenaline Homeostasis in Rats with Painful Diabetic Neuropathy as a Target of Duloxetine Analgesia

Overview of attention for article published in Molecular Pain, January 2013
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2 X users
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1 Redditor

Citations

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67 Mendeley
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Title
Impaired Noradrenaline Homeostasis in Rats with Painful Diabetic Neuropathy as a Target of Duloxetine Analgesia
Published in
Molecular Pain, January 2013
DOI 10.1186/1744-8069-9-59
Pubmed ID
Authors

Jun Kinoshita, Yukari Takahashi, Ayako M Watabe, Kazunori Utsunomiya, Fusao Kato

Abstract

Painful diabetic neuropathy (PDN) is a serious complication of diabetes mellitus that affects a large number of patients in many countries. The molecular mechanisms underlying the exaggerated nociception in PDN have not been established. Recently, duloxetine (DLX), a serotonin and noradrenaline re-uptake inhibitor, has been recommended as one of the first-line treatments of PDN in the United States Food and Drug Administration, the European Medicines Agency and the Japanese Guideline for the Pharmacologic Management of Neuropathic pain. Because selective serotonin re-uptake inhibitors show limited analgesic effects in PDN, we examined whether the potent analgesic effect of DLX contributes toward improving the pathologically aberrant noradrenaline homeostasis in diabetic models.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
France 1 1%
India 1 1%
Russia 1 1%
Spain 1 1%
Unknown 62 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 16%
Student > Ph. D. Student 9 13%
Student > Master 7 10%
Student > Doctoral Student 6 9%
Professor > Associate Professor 4 6%
Other 19 28%
Unknown 11 16%
Readers by discipline Count As %
Medicine and Dentistry 16 24%
Neuroscience 13 19%
Agricultural and Biological Sciences 10 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Unspecified 3 4%
Other 8 12%
Unknown 13 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2014.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Molecular Pain
#447
of 669 outputs
Outputs of similar age
#221,304
of 288,991 outputs
Outputs of similar age from Molecular Pain
#35
of 41 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,991 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.