Title |
Impaired Noradrenaline Homeostasis in Rats with Painful Diabetic Neuropathy as a Target of Duloxetine Analgesia
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Published in |
Molecular Pain, January 2013
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DOI | 10.1186/1744-8069-9-59 |
Pubmed ID | |
Authors |
Jun Kinoshita, Yukari Takahashi, Ayako M Watabe, Kazunori Utsunomiya, Fusao Kato |
Abstract |
Painful diabetic neuropathy (PDN) is a serious complication of diabetes mellitus that affects a large number of patients in many countries. The molecular mechanisms underlying the exaggerated nociception in PDN have not been established. Recently, duloxetine (DLX), a serotonin and noradrenaline re-uptake inhibitor, has been recommended as one of the first-line treatments of PDN in the United States Food and Drug Administration, the European Medicines Agency and the Japanese Guideline for the Pharmacologic Management of Neuropathic pain. Because selective serotonin re-uptake inhibitors show limited analgesic effects in PDN, we examined whether the potent analgesic effect of DLX contributes toward improving the pathologically aberrant noradrenaline homeostasis in diabetic models. |
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Mendeley readers
Geographical breakdown
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