#34 κ/λ Light Chain (R)atio 1) κ/λ are cleared by kidney and reticulo-endothelial system (RES) 2) κ/λ cells are in ~2:1 ratio; but kidney clears monomeric κ more than dimeric λ, hence R<1 3) In CKD, κ/λ cleared less by kidney, more by RES, hence R>
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Free light chain ratio increases with worsening renal function. But a ratio above 3.1 should be concerning for monoclonal pathology. https://t.co/VpRd6oN4oG
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RT @edgarvlermamd: MT @HofstraKidney LEUNG: Serum free light chain assays - best test for diagnosis & treatment F/U #Nephpearls #SCM17 #Nep…
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MT @HofstraKidney LEUNG: Serum free light chain assays - best test for diagnosis & treatment F/U #Nephpearls #SCM17 #NephJC 👉🏼 https://t.co/VgmAYEby0J https://t.co/VWq1fHNjvG