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Parental olfactory experience influences behavior and neural structure in subsequent generations

Overview of attention for article published in Nature Neuroscience, December 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 5,091)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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838 Dimensions

Readers on

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2373 Mendeley
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7 CiteULike
Title
Parental olfactory experience influences behavior and neural structure in subsequent generations
Published in
Nature Neuroscience, December 2013
DOI 10.1038/nn.3594
Pubmed ID
Authors

Brian G Dias, Kerry J Ressler

Abstract

Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2 generations had an increased behavioral sensitivity to the F0-conditioned odor, but not to other odors. When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene. In addition, in vitro fertilization, F2 inheritance and cross-fostering revealed that these transgenerational effects are inherited via parental gametes. Our findings provide a framework for addressing how environmental information may be inherited transgenerationally at behavioral, neuroanatomical and epigenetic levels.

Twitter Demographics

The data shown below were collected from the profiles of 846 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 2,373 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 46 2%
Germany 16 <1%
Japan 15 <1%
France 10 <1%
Canada 10 <1%
United Kingdom 9 <1%
Spain 5 <1%
Portugal 5 <1%
Netherlands 4 <1%
Other 52 2%
Unknown 2201 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 580 24%
Researcher 410 17%
Student > Bachelor 351 15%
Student > Master 255 11%
Student > Doctoral Student 135 6%
Other 432 18%
Unknown 210 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 914 39%
Biochemistry, Genetics and Molecular Biology 275 12%
Neuroscience 259 11%
Psychology 232 10%
Medicine and Dentistry 162 7%
Other 250 11%
Unknown 281 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1783. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2022.
All research outputs
#4,187
of 21,429,365 outputs
Outputs from Nature Neuroscience
#9
of 5,091 outputs
Outputs of similar age
#28
of 304,318 outputs
Outputs of similar age from Nature Neuroscience
#2
of 80 outputs
Altmetric has tracked 21,429,365 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,091 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 50.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.